Bryan T. Hennessy

Research interests

Publications

• Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer

  New England Journal of Medicine · 2025 · https://doi.org/10.1056/nejmoa2406070

• Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study

  JAMA Neurology · 2021 · https://doi.org/10.1001/jamaneurol.2021.0405

• Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer

  Clinical Cancer Research · 2016 · https://doi.org/10.1158/1078-0432.ccr-15-2477

• Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis

  Carcinogenesis · 2013 · https://doi.org/10.1093/carcin/bgt208

• Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

  Breast Cancer Research · 2013 · 10.1186/bcr3493

• Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

  British Journal of Cancer · 2012 · 10.1038/bjc.2012.451

• Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement

  Annals of Oncology · 2012 · 10.1093/annonc/mds586

• Subtype and pathway specific responses to anticancer compounds in breast cancer

  Proceedings of the National Academy of Sciences · 2011 · https://doi.org/10.1073/pnas.1018854108

• High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

  Cancer Discovery · 2011 · 10.1158/2159-8290.cd-11-0039

• Incidence and Outcome of BRCA Mutations in Unselected Patients with Triple Receptor-Negative Breast Cancer

  Clinical Cancer Research · 2011 · 10.1158/1078-0432.ccr-10-2560

• Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

  Journal of Clinical Investigation · 2011 · 10.1172/jci44145

• Future of Personalized Medicine in Oncology: A Systems Biology Approach

  Journal of Clinical Oncology · 2010 · 10.1200/jco.2009.27.0777

• Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer

  Journal of Clinical Oncology · 2010 · 10.1200/jco.2009.27.2997

• PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor–positive breast cancer

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.0907011107

• Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer

  Journal of Clinical Investigation · 2010 · 10.1172/jci41680

• Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

  Cancer Research · 2009 · https://doi.org/10.1158/0008-5472.can-08-3441

• Ovarian cancer

  The Lancet · 2009 · 10.1016/s0140-6736(09)61338-6

• The biology of ovarian cancer: new opportunities for translation

  Nature reviews. Cancer · 2009 · https://doi.org/10.1038/nrc2644

• An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

  Cancer Research · 2008 · 10.1158/0008-5472.can-07-6854

• Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer

  Journal of Clinical Oncology · 2008 · https://doi.org/10.1200/jco.2007.14.4147

• Measurement of Residual Breast Cancer Burden to Predict Survival After Neoadjuvant Chemotherapy

  Journal of Clinical Oncology · 2007 · https://doi.org/10.1200/jco.2007.10.6823

• The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

  Nature Cell Biology · 2007 · 10.1038/ncb1537

• A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer

  Cancer Cell · 2007 · https://doi.org/10.1016/j.ccr.2007.08.030

• Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

  Molecular Cancer Therapeutics · 2006 · 10.1158/1535-7163.mct-06-0334

• Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

  Nature Reviews Drug Discovery · 2005 · https://doi.org/10.1038/nrd1902

• Outcome After Pathologic Complete Eradication of Cytologically Proven Breast Cancer Axillary Node Metastases Following Primary Chemotherapy

  Journal of Clinical Oncology · 2005 · 10.1200/jco.2005.02.5023

Current projects

No projects listed.