Muhammad Zaeem Noman

Research interests

Publications

• Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy

  Oncogene · 2021 · 10.1038/s41388-021-01846-x

• Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy

  Oncogene · 2021 · 10.1038/s41388-021-01846-x

• Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy

  Oncogene · 2021 · 10.1038/s41388-021-01846-x

• Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

  Science Advances · 2020 · 10.1126/sciadv.aax7881

• The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

  Cells · 2019 · 10.3390/cells8060613

• Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

  Cancer Letters · 2019 · 10.1016/j.canlet.2019.05.021

• Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

  Cells · 2019 · 10.3390/cells8091083

• Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

  Cancer Letters · 2019 · 10.1016/j.canlet.2019.05.021

• Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

  Cancer Letters · 2019 · 10.1016/j.canlet.2019.05.021

• The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

  OncoImmunology · 2017 · 10.1080/2162402x.2016.1263412

• Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

  Proceedings of the National Academy of Sciences · 2017 · 10.1073/pnas.1703921114

• Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

  Oncogene · 2016 · 10.1038/onc.2016.225

• Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status

  European Urology · 2015 · 10.1016/j.eururo.2015.11.029

• Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

  American Journal of Physiology-Cell Physiology · 2015 · 10.1152/ajpcell.00207.2015

• The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

  Journal of Biological Chemistry · 2015 · 10.1074/jbc.m115.651547

• Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

  OncoImmunology · 2015 · 10.1080/2162402x.2015.1062968

• Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress

  Frontiers in Immunology · 2015 · 10.3389/fimmu.2015.00482

• Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210

  Cancer Research · 2015 · 10.1158/0008-5472.can-15-0405

• PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

  The Journal of Experimental Medicine · 2014 · https://doi.org/10.1084/jem.20131916

• ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy

  Cancer Research · 2014 · 10.1158/0008-5472.can-14-0303

• Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1304790110

• Cutting Edge: Hypoxia-Induced Nanog Favors the Intratumoral Infiltration of Regulatory T Cells and Macrophages via Direct Regulation of TGF-β1

  The Journal of Immunology · 2013 · 10.4049/jimmunol.1302140

• Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis

  Cancer Research · 2013 · 10.1158/0008-5472.can-12-2432

• Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape

  Frontiers in Immunology · 2012 · 10.3389/fimmu.2012.00021

• Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells

  Cancer Research · 2012 · 10.1158/0008-5472.can-12-1383

• Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

  Cancer Research · 2011 · 10.1158/0008-5472.can-11-1094

• Microenvironmental Hypoxia Orchestrating the Cell Stroma Cross Talk, Tumor Progression and Antitumor Response

  Critical Reviews in Immunology · 2011 · 10.1615/critrevimmunol.v31.i5.10

• Endothelial Cells as Key Determinants of the Tumor Microenvironment: Interaction with Tumor Cells, Extracellular Matrix and Immune Killer Cells

  Critical Reviews in Immunology · 2010 · 10.1615/critrevimmunol.v30.i6.30

• The Cooperative Induction of Hypoxia-Inducible Factor-1α and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis

  The Journal of Immunology · 2009 · 10.4049/jimmunol.0800854

Current projects

No projects listed.