Yasuo Uchiyama

Research interests

Publications

• Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

  Nature Medicine · 2023 · https://doi.org/10.1038/s41591-023-02358-9

• CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study

  The Lancet Neurology · 2015 · https://doi.org/10.1016/s1474-4422(14)70266-2

• Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

  Molecular Brain · 2012 · https://doi.org/10.1186/1756-6606-5-35

• Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice

  Proceedings of the National Academy of Sciences · 2011 · https://doi.org/10.1073/pnas.1108077108

• Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.05.008

• The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes

  The EMBO Journal · 2009 · https://doi.org/10.1038/emboj.2008.308

• The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

  Molecular Biology of the Cell · 2008 · https://doi.org/10.1091/mbc.e08-03-0309

• Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

  American Journal Of Pathology · 2008 · https://doi.org/10.2353/ajpath.2008.070876

• Regulation of Autophagy by Extracellular Signal-Regulated Protein Kinases During 1-Methyl-4-Phenylpyridinium-Induced Cell Death

  American Journal Of Pathology · 2007 · https://doi.org/10.2353/ajpath.2007.060524

• Identification of Tim4 as a phosphatidylserine receptor

  Nature · 2007 · https://doi.org/10.1038/nature06307

• Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.10.035

• Loss of autophagy in the central nervous system causes neurodegeneration in mice

  Nature · 2006 · https://doi.org/10.1038/nature04723

• Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

  The Journal of Cell Biology · 2005 · https://doi.org/10.1083/jcb.200505082

• Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

  Nature · 2005 · https://doi.org/10.1038/nature03964

• Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)

  American Journal Of Pathology · 2005 · https://doi.org/10.1016/s0002-9440(10)61253-9

• Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice

  The Journal of Cell Biology · 2005 · https://doi.org/10.1083/jcb.200412022

• Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

  Science · 2004 · 10.1126/science.1094359

• The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia

  Cell Death and Differentiation · 2004 · https://doi.org/10.1038/sj.cdd.4401545

• Transplantation of in vitro‐expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

  Journal of Neuroscience Research · 2002 · https://doi.org/10.1002/jnr.10341

• RNA-binding protein Musashi family: Roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation

  Proceedings of the National Academy of Sciences · 2002 · https://doi.org/10.1073/pnas.232087499

• Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain

  Journal of Neuropathology & Experimental Neurology · 2001 · https://doi.org/10.1093/jnen/60.2.161

• Requirement of DNase II for Definitive Erythropoiesis in the Mouse Fetal Liver

  Science · 2001 · https://doi.org/10.1126/science.292.5521.1546

• Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons

  Journal of Neuroscience · 2000 · https://doi.org/10.1523/jneurosci.20-18-06898.2000

• Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

  The Journal of Cell Biology · 1998 · https://doi.org/10.1083/jcb.143.5.1353

• Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

  Journal of Neuroscience · 1995 · https://doi.org/10.1523/jneurosci.15-02-01001.1995

Current projects

No projects listed.