Mark P. Mattson

Research interests

Publications

• Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

  Nature Reviews Drug Discovery · 2020 · https://doi.org/10.1038/s41573-020-0072-x

• Effects of Intermittent Fasting on Health, Aging, and Disease

  New England Journal of Medicine · 2019 · 10.1056/nejmra1905136

• Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

  Nature Neuroscience · 2019 · https://doi.org/10.1038/s41593-019-0372-9

• Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

  Nature Neuroscience · 2019 · https://doi.org/10.1038/s41593-018-0332-9

• Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

  Cell Metabolism · 2018 · 10.1016/j.cmet.2018.05.011

• Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

  Trends in Neurosciences · 2017 · https://doi.org/10.1016/j.tins.2017.01.002

• Impact of intermittent fasting on health and disease processes

  Ageing Research Reviews · 2016 · 10.1016/j.arr.2016.10.005

• Fasting: Molecular Mechanisms and Clinical Applications

  Cell Metabolism · 2014 · 10.1016/j.cmet.2013.12.008

• Meal frequency and timing in health and disease

  Proceedings of the National Academy of Sciences · 2014 · https://doi.org/10.1073/pnas.1413965111

• The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

  International Journal of Obesity · 2010 · https://doi.org/10.1038/ijo.2010.171

• GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0806720106

• Mitochondria in Neuroplasticity and Neurological Disorders

  Neuron · 2008 · 10.1016/j.neuron.2008.10.010

• Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

  Trends in Neurosciences · 2008 · https://doi.org/10.1016/j.tins.2008.06.005

• Hormesis defined

  Ageing Research Reviews · 2007 · 10.1016/j.arr.2007.08.007

• Ageing and neuronal vulnerability

  Nature reviews. Neuroscience · 2006 · 10.1038/nrn1886

• Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

  Science · 2005 · https://doi.org/10.1126/science.1105850

• Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0305799101

• Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0405831102

• Pathways towards and away from Alzheimer's disease

  Nature · 2004 · https://doi.org/10.1038/nature02621

• BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

  Trends in Neurosciences · 2004 · https://doi.org/10.1016/j.tins.2004.08.001

• Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

  Neuron · 2003 · https://doi.org/10.1016/s0896-6273(03)00434-3

• Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

  Journal of Neurochemistry · 2002 · https://doi.org/10.1046/j.1471-4159.2002.01085.x

• Apoptosis in neurodegenerative disorders

  Nature Reviews Molecular Cell Biology · 2000 · https://doi.org/10.1038/35040009

• Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

  Physiological Reviews · 1997 · https://doi.org/10.1152/physrev.1997.77.4.1081

• Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

  Nature Medicine · 1996 · https://doi.org/10.1038/nm0796-788

• A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

  Proceedings of the National Academy of Sciences · 1994 · 10.1073/pnas.91.8.3270

Current projects

No projects listed.