Ralph H. Hruban

Research interests

Publications

• Proteogenomic characterization of pancreatic ductal adenocarcinoma

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.08.023

• Detection and localization of surgically resectable cancers with a multi-analyte blood test

  Science · 2018 · https://doi.org/10.1126/science.aar3247

• Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-18-0349

• Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.07.007

• Pancreatic cancer

  Nature Reviews Disease Primers · 2016 · 10.1038/nrdp.2016.22

• Genomic analyses identify molecular subtypes of pancreatic cancer

  Nature · 2016 · https://doi.org/10.1038/nature16965

• PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

  New England Journal of Medicine · 2015 · https://doi.org/10.1056/nejmoa1500596

• Whole genomes redefine the mutational landscape of pancreatic cancer

  Nature · 2015 · 10.1038/nature14169

• Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

  Science Translational Medicine · 2014 · https://doi.org/10.1126/scitranslmed.3007094

• A draft map of the human proteome

  Nature · 2014 · 10.1038/nature13302

• Organoid Models of Human and Mouse Ductal Pancreatic Cancer

  Cell · 2014 · 10.1016/j.cell.2014.12.021

• Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

  Nature Genetics · 2013 · 10.1038/ng.2813

• TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1303607110

• Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

  Nature · 2012 · 10.1038/nature11547

• Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

  Science · 2011 · 10.1126/science.1206923

• Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

  Science Translational Medicine · 2011 · 10.1126/scitranslmed.3002543

• DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

  Science · 2011 · 10.1126/science.1200609

• Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

  Nature · 2011 · 10.1038/nature10189

• Distant metastasis occurs late during the genetic evolution of pancreatic cancer

  Nature · 2010 · 10.1038/nature09515

• Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

  Science · 2009 · https://doi.org/10.1126/science.1171362

• Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

  Science · 2008 · https://doi.org/10.1126/science.1164368

• 1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience

  Journal of Gastrointestinal Surgery · 2006 · 10.1016/j.gassur.2006.08.018

• Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

  Cancer Cell · 2005 · 10.1016/j.ccr.2005.04.023

• Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

  Cancer Cell · 2003 · 10.1016/s1535-6108(03)00309-x

• Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy

  New England Journal of Medicine · 2000 · 10.1056/nejm200004133421502

• Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s

  Annals of Surgery · 1997 · 10.1097/00000658-199709000-00004

• DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

  Science · 1996 · 10.1126/science.271.5247.350

• Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

  Nature Genetics · 1994 · 10.1038/ng0994-27

Current projects

No projects listed.