Thomas Härtung

Research interests

Publications

• Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

  Frontiers in Science · 2023 · https://doi.org/10.3389/fsci.2023.1017235

• New approach methodologies in human regulatory toxicology – Not if, but how and when!

  Environment International · 2023 · https://doi.org/10.1016/j.envint.2023.108082

• Toxicity testing in the 21st century: progress in the past decade and future perspectives

  Archives of Toxicology · 2019 · https://doi.org/10.1007/s00204-019-02613-4

• Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility

  Toxicological Sciences · 2018 · https://doi.org/10.1093/toxsci/kfy152

• Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

  Scientific Reports · 2017 · https://doi.org/10.1038/s41598-017-08879-x

• Adverse outcome pathways: opportunities, limitations and open questions

  Archives of Toxicology · 2017 · https://doi.org/10.1007/s00204-017-2045-3

• Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

  Regulatory Toxicology and Pharmacology · 2014 · https://doi.org/10.1016/j.yrtph.2014.09.009

• “ToxRTool”, a new tool to assess the reliability of toxicological data

  Toxicology Letters · 2009 · https://doi.org/10.1016/j.toxlet.2009.05.013

• Toxicology for the twenty-first century

  Nature · 2009 · https://doi.org/10.1038/460208a

• Membrane Sorting of Toll-like Receptor (TLR)-2/6 and TLR2/1 Heterodimers at the Cell Surface Determines Heterotypic Associations with CD36 and Intracellular Targeting

  Journal of Biological Chemistry · 2006 · https://doi.org/10.1074/jbc.m602794200

• Prevalence ofBorrelia burgdorferiSensu Lato Genospecies inIxodes ricinusTicks in Europe: a Metaanalysis

  Applied and Environmental Microbiology · 2005 · https://doi.org/10.1128/aem.71.11.7203-7216.2005

• CD36 is a sensor of diacylglycerides

  Nature · 2005 · https://doi.org/10.1038/nature03253

• Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0504084102

• Guidance on Good Cell Culture Practice

  Alternatives to Laboratory Animals · 2005 · https://doi.org/10.1177/026119290503300313

• Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

  The Journal of Immunology · 2004 · https://doi.org/10.4049/jimmunol.172.6.3712

• A Modular Approach to the ECVAM Principles on Test Validity

  Alternatives to Laboratory Animals · 2004 · https://doi.org/10.1177/026119290403200503

• Innate immunity in Arabidopsis thaliana : Lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0404536101

• Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m212829200

• Structure–Function Relationship of Cytokine Induction by Lipoteichoic Acid fromStaphylococcus aureus

  The Journal of Experimental Medicine · 2001 · https://doi.org/10.1084/jem.193.3.393

• The Role of Toll-like Receptors (TLRs) in Bacteria-induced Maturation of Murine Dendritic Cells (DCs)

  Journal of Biological Chemistry · 2001 · https://doi.org/10.1074/jbc.m011615200

• Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

  European Journal of Immunology · 2001 · https://doi.org/10.1002/1521-4141(200111)31:11<3153::aid-immu3153>3.0.co;2-0

• Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators

  The Journal of Immunology · 2001 · https://doi.org/10.4049/jimmunol.166.8.5161

• Interleukin-10 Counterregulates Proinflammatory Cytokine-Induced Inhibition of Neutrophil Apoptosis During Severe Sepsis

  Blood · 1997 · https://doi.org/10.1182/blood.v90.9.3356

• Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers

  Blood · 1995 · https://doi.org/10.1182/blood.v85.9.2482.bloodjournal8592482

Current projects

No projects listed.