Yun Dai

Research interests

Publications

• Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage

  Human Reproduction Update · 2024 · 10.1093/humupd/dmae020

• Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage

  Human Reproduction Update · 2024 · 10.1093/humupd/dmae020

• d -lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma

  Science Advances · 2023 · https://doi.org/10.1126/sciadv.adg2697

• Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel promotes diabetic wound healing

  Materials Today Bio · 2021 · 10.1016/j.mtbio.2021.100139

• A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer

  Acta Pharmaceutica Sinica B · 2021 · 10.1016/j.apsb.2021.06.005

• Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel promotes diabetic wound healing

  Materials Today Bio · 2021 · 10.1016/j.mtbio.2021.100139

• Programmed Death-Ligand 1 Expression Predicts Tyrosine Kinase Inhibitor Response and Better Prognosis in a Cohort of Patients With Epidermal Growth Factor Receptor Mutation-Positive Lung Adenocarcinoma

  Clinical Lung Cancer · 2015 · 10.1016/j.cllc.2015.02.002

• Programmed Death-Ligand 1 Expression Predicts Tyrosine Kinase Inhibitor Response and Better Prognosis in a Cohort of Patients With Epidermal Growth Factor Receptor Mutation-Positive Lung Adenocarcinoma

  Clinical Lung Cancer · 2015 · 10.1016/j.cllc.2015.02.002

• Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes: A Meta-Analysis

  The Oncologist · 2015 · 10.1634/theoncologist.2015-0096

• Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes: A Meta-Analysis

  The Oncologist · 2015 · 10.1634/theoncologist.2015-0096

• Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

  Pharmacology & Therapeutics · 2014 · https://doi.org/10.1016/j.pharmthera.2014.04.004

• Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

  FEBS Journal · 2012 · 10.1111/j.1742-4658.2012.08748.x

• New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

  Clinical Cancer Research · 2010 · https://doi.org/10.1158/1078-0432.ccr-09-1029

• Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2, Bcl-xL, and Mcl-1

  Molecular and Cellular Biology · 2009 · 10.1128/mcb.01481-08

• Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2, Bcl-xL, and Mcl-1

  Molecular and Cellular Biology · 2009 · 10.1128/mcb.01481-08

• Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

  Blood · 2008 · 10.1182/blood-2008-05-159392

• Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

  Blood · 2008 · 10.1182/blood-2008-05-159392

• Targeting Multiple Arms of the Apoptotic Regulatory Machinery

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-0082

• Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation

  Cancer Research · 2007 · https://doi.org/10.1158/0008-5472.can-06-3964

• Targeting Multiple Arms of the Apoptotic Regulatory Machinery

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-0082

• Coadministration of Histone Deacetylase Inhibitors and Perifosine Synergistically Induces Apoptosis in Human Leukemia Cells through Akt and ERK1/2 Inactivation and the Generation of Ceramide and Reactive Oxygen Species

  Cancer Research · 2005 · 10.1158/0008-5472.can-04-2440

• Blockade of Histone Deacetylase Inhibitor-Induced RelA/p65 Acetylation and NF-κB Activation Potentiates Apoptosis in Leukemia Cells through a Process Mediated by Oxidative Damage, XIAP Downregulation, and c-Jun N-Terminal Kinase 1 Activation

  Molecular and Cellular Biology · 2005 · 10.1128/mcb.25.13.5429-5444.2005

• Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors

  Clinical Cancer Research · 2004 · https://doi.org/10.1158/1078-0432.ccr-03-0561

• A Bcr/Abl-independent, Lyn-dependent Form of Imatinib Mesylate (STI-571) Resistance Is Associated with Altered Expression of Bcl-2

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m402290200

• The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

  Cancer Research · 2004 · 10.1158/0008-5472.can-03-2631

• The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

  Cancer Research · 2004 · 10.1158/0008-5472.can-03-2631

• Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms

  Blood · 2004 · 10.1182/blood-2003-12-4121

• Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms

  Blood · 2004 · 10.1182/blood-2003-12-4121

• The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

  Leukemia · 2003 · 10.1038/sj.leu.2403109

• Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.

  PubMed · 2003

• Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.

  PubMed · 2003

• The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

  Leukemia · 2003 · 10.1038/sj.leu.2403109

• Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process

  Oncogene · 2003 · 10.1038/sj.onc.1206863

• Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.

  PubMed · 2003

• Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process

  Oncogene · 2003 · 10.1038/sj.onc.1206863

• Cyclin-dependent kinase inhibitors

  Current Opinion in Pharmacology · 2003 · 10.1016/s1471-4892(03)00079-1

• Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.

  PubMed · 2001

Current projects

No projects listed.