María E. Figueroa

Research interests

Publications

• IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

  Science Translational Medicine · 2019 · 10.1126/scitranslmed.aaq1427

• Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia

  Cancer Discovery · 2019 · 10.1158/2159-8290.cd-18-1474

• Autophagy maintains the metabolism and function of young and old stem cells

  Nature · 2017 · 10.1038/nature21388

• Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

  Cell · 2017 · 10.1016/j.cell.2017.07.032

• Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

  Nature Communications · 2016 · 10.1038/ncomms10767

• Prolonged Administration of Azacitidine With or Without Entinostat for Myelodysplastic Syndrome and Acute Myeloid Leukemia With Myelodysplasia-Related Changes: Results of the US Leukemia Intergroup Trial E1905

  Journal of Clinical Oncology · 2014 · 10.1200/jco.2013.50.3102

• DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

  Cell Reports · 2014 · 10.1016/j.celrep.2014.11.004

• MethylSig: a whole genome DNA methylation analysis pipeline

  Bioinformatics · 2014 · 10.1093/bioinformatics/btu339

• DNMT1-interacting RNAs block gene-specific DNA methylation

  Nature · 2013 · 10.1038/nature12598

• Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

  Leukemia · 2012 · 10.1038/leu.2012.363

• methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

  Genome biology · 2012 · https://doi.org/10.1186/gb-2012-13-10-r87

• Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1112304

• A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

  Cell · 2012 · 10.1016/j.cell.2012.11.039

• Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

  Nature Genetics · 2012 · 10.1038/ng.2413

• IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

  Nature · 2012 · 10.1038/nature11323

• Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

  PLoS Genetics · 2012 · 10.1371/journal.pgen.1002781

• Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

  Blood · 2012 · 10.1182/blood-2011-07-367961

• IDH mutation impairs histone demethylation and results in a block to cell differentiation

  Nature · 2012 · https://doi.org/10.1038/nature10860

• Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

  Cancer Cell · 2011 · https://doi.org/10.1016/j.ccr.2011.06.001

• DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

  Cancer Cell · 2010 · 10.1016/j.ccr.2009.11.020

• Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

  Nature Biotechnology · 2010 · 10.1038/nbt.1667

• Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2010.11.015

• MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

  Blood · 2009 · 10.1182/blood-2009-01-200519

• HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

  Molecular Biology of the Cell · 2008 · 10.1091/mbc.e08-02-0139

• Comparative isoschizomer profiling of cytosine methylation: The HELP assay

  Genome Research · 2006 · 10.1101/gr.5273806

Current projects

No projects listed.