Leo A. B. Joosten

Research interests

Publications

• Presence of Genetic Variants Among Young Men With Severe COVID-19

  JAMA · 2020 · 10.1001/jama.2020.13719

• Trained immunity, tolerance, priming and differentiation: distinct immunological processes

  Nature Immunology · 2020 · https://doi.org/10.1038/s41590-020-00845-6

• Defining trained immunity and its role in health and disease

  Nature reviews. Immunology · 2020 · https://doi.org/10.1038/s41577-020-0285-6

• Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0350-x

• Gout

  Nature Reviews Disease Primers · 2019 · 10.1038/s41572-019-0115-y

• Metabolic Induction of Trained Immunity through the Mevalonate Pathway

  Cell · 2018 · 10.1016/j.cell.2017.11.025

• Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

  Cell · 2018 · 10.1016/j.cell.2017.11.034

• BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

  Cell Host & Microbe · 2018 · https://doi.org/10.1016/j.chom.2017.12.010

• Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

  Cell · 2018 · https://doi.org/10.1016/j.cell.2017.12.013

• A guiding map for inflammation

  Nature Immunology · 2017 · 10.1038/ni.3790

• Immunometabolic Pathways in BCG-Induced Trained Immunity

  Cell Reports · 2016 · 10.1016/j.celrep.2016.11.011

• Trained immunity: A program of innate immune memory in health and disease

  Science · 2016 · https://doi.org/10.1126/science.aaf1098

• Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

  Cell · 2016 · 10.1016/j.cell.2016.10.020

• Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.10.008

• The effect of host genetics on the gut microbiome

  Nature Genetics · 2016 · 10.1038/ng.3663

• Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

  Nature Immunology · 2016 · 10.1038/ni.3398

• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  Science · 2014 · https://doi.org/10.1126/science.1250684

• Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

  Arteriosclerosis Thrombosis and Vascular Biology · 2014 · 10.1161/atvbaha.114.303887

• Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

  Science · 2014 · https://doi.org/10.1126/science.1251086

• Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

  Cell Host & Microbe · 2012 · 10.1016/j.chom.2012.06.006

• Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1202870109

• Inflammasome is a central player in the induction of obesity and insulin resistance

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1100255108

• Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

  Nature Genetics · 2011 · 10.1038/ng.998

• Inflammasome activation and IL-1β and IL-18 processing during infection

  Trends in Immunology · 2011 · 10.1016/j.it.2011.01.003

• Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

  New England Journal of Medicine · 2009 · 10.1056/nejmoa0901053

• Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

  Blood · 2008 · 10.1182/blood-2008-03-146720

• Treatment with a neutralizing anti‐murine interleukin‐17 antibody after the onset of collagen‐induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

  Arthritis & Rheumatism · 2004 · 10.1002/art.20001

Current projects

No projects listed.