J.W.M. van der Meer

Research interests

Publications

• Defining trained immunity and its role in health and disease

  Nature reviews. Immunology · 2020 · https://doi.org/10.1038/s41577-020-0285-6

• Presence of Genetic Variants Among Young Men With Severe COVID-19

  JAMA · 2020 · 10.1001/jama.2020.13719

• Trained immunity, tolerance, priming and differentiation: distinct immunological processes

  Nature Immunology · 2020 · https://doi.org/10.1038/s41590-020-00845-6

• Metabolic Induction of Trained Immunity through the Mevalonate Pathway

  Cell · 2018 · https://doi.org/10.1016/j.cell.2017.11.025

• Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

  Cell Metabolism · 2016 · https://doi.org/10.1016/j.cmet.2016.10.008

• Host and Environmental Factors Influencing Individual Human Cytokine Responses

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.10.018

• Immune defence against Candida fungal infections

  Nature reviews. Immunology · 2015 · 10.1038/nri3897

• BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

  Clinical Immunology · 2014 · 10.1016/j.clim.2014.10.005

• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  Science · 2014 · https://doi.org/10.1126/science.1250684

• Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

  Science · 2014 · https://doi.org/10.1126/science.1251086

• Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

  Arteriosclerosis Thrombosis and Vascular Biology · 2014 · 10.1161/atvbaha.114.303887

• Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

  Journal of Innate Immunity · 2013 · 10.1159/000355628

• Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1202870109

• Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

  Cell Host & Microbe · 2012 · 10.1016/j.chom.2012.06.006

• STAT1 Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis

  New England Journal of Medicine · 2011 · 10.1056/nejmoa1100102

• Trained Immunity: A Memory for Innate Host Defense

  Cell Host & Microbe · 2011 · 10.1016/j.chom.2011.04.006

• Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

  New England Journal of Medicine · 2009 · 10.1056/nejmoa0901053

• The role of TNF-α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk

  Journal of Lipid Research · 2007 · 10.1194/jlr.r600021-jlr200

• Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

  The Journal of Immunology · 2004 · 10.4049/jimmunol.172.6.3712

• Innate Immunity toMycobacterium tuberculosis

  Clinical Microbiology Reviews · 2002 · 10.1128/cmr.15.2.294-309.2002

• Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes

  Journal of Pharmacology and Experimental Therapeutics · 2000 · 10.1016/s0022-3565(24)35391-1

• Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

  Clinical Microbiology Reviews · 2000 · 10.1128/cmr.13.1.144-166.2000

• Cytokine Patterns in Patients After Major Vascular Surgery, Hemorrhagic Shock, and Severe Blunt Trauma Relation with Subsequent Adult Respiratory Distress Syndrome and Multiple Organ Failure

  Annals of Surgery · 1993 · 10.1097/00000658-199312000-00011

• Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever

  The Journal of Infectious Diseases · 1990 · 10.1093/infdis/161.1.79

• The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

  New England Journal of Medicine · 1989 · https://doi.org/10.1056/nejm198902023200501

Current projects

No projects listed.