Alun D. Hughes

Research interests

Publications

• Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

  Science · 2021 · https://doi.org/10.1126/science.abh1282

• Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

  Nature · 2021 · https://doi.org/10.1038/s41586-021-04186-8

• Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

  The Lancet Diabetes & Endocrinology · 2017 · https://doi.org/10.1016/s2213-8587(17)30194-8

• Accuracy of Cuff-Measured Blood Pressure

  Journal of the American College of Cardiology · 2017 · https://doi.org/10.1016/j.jacc.2017.05.064

• Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes

  Diabetes · 2016 · https://doi.org/10.2337/db16-0731

• Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization

  European Heart Journal · 2016 · https://doi.org/10.1093/eurheartj/ehw632

• Metabolite Profiling and Cardiovascular Event Risk

  Circulation · 2015 · https://doi.org/10.1161/circulationaha.114.013116

• Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study

  Diabetologia · 2015 · https://doi.org/10.1007/s00125-015-3517-8

• Differences in smoking associated DNA methylation patterns in South Asians and Europeans

  Clinical Epigenetics · 2014 · https://doi.org/10.1186/1868-7083-6-4

• Diagnostic Classification of the Instantaneous Wave-Free Ratio Is Equivalent to Fractional Flow Reserve and Is Not Improved With Adenosine Administration

  Journal of the American College of Cardiology · 2013 · https://doi.org/10.1016/j.jacc.2013.01.034

• The Relationship Between Metabolic Risk Factors and Incident Cardiovascular Disease in Europeans, South Asians, and African Caribbeans

  Journal of the American College of Cardiology · 2013 · https://doi.org/10.1016/j.jacc.2012.12.046

• First-in-man safety evaluation of renal denervation for chronic systolic heart failure: Primary outcome from REACH-Pilot study

  International Journal of Cardiology · 2012 · https://doi.org/10.1016/j.ijcard.2012.09.019

• Cohort Profile: Updating the cohort profile for the MRC National Survey of Health and Development: a new clinic-based data collection for ageing research

  International Journal of Epidemiology · 2011 · https://doi.org/10.1093/ije/dyq231

• Development and Validation of a New Adenosine-Independent Index of Stenosis Severity From Coronary Wave–Intensity Analysis

  Journal of the American College of Cardiology · 2011 · https://doi.org/10.1016/j.jacc.2011.11.003

• Endothelial von Willebrand factor regulates angiogenesis

  Blood · 2010 · https://doi.org/10.1182/blood-2010-01-264507

• Segmentation of blood vessels from red-free and fluorescein retinal images

  Medical Image Analysis · 2007 · https://doi.org/10.1016/j.media.2006.11.004

• Abnormalities of Retinal Microvascular Structure and Risk of Mortality From Ischemic Heart Disease and Stroke

  Hypertension · 2006 · https://doi.org/10.1161/01.hyp.0000216717.72048.6c

• Differential Impact of Blood Pressure–Lowering Drugs on Central Aortic Pressure and Clinical Outcomes

  Circulation · 2006 · https://doi.org/10.1161/circulationaha.105.595496

• Evidence of a Dominant Backward-Propagating “Suction” Wave Responsible for Diastolic Coronary Filling in Humans, Attenuated in Left Ventricular Hypertrophy

  Circulation · 2006 · https://doi.org/10.1161/circulationaha.105.603050

• A perspective of polyamine metabolism

  Biochemical Journal · 2003 · https://doi.org/10.1042/bj20031327

• Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation

  Journal of Biomechanics · 2000 · https://doi.org/10.1016/s0021-9290(00)00043-9

Current projects

No projects listed.