Hiroyuki Aburatani

Research interests

Publications

• The landscape of viral associations in human cancers

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0558-9

• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0576-7

• Integrative Molecular Characterization of Malignant Pleural Mesothelioma

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-18-0804

• Engineered CRISPR-Cas9 nuclease with expanded targeting space

  Science · 2018 · https://doi.org/10.1126/science.aas9129

• Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3547

• Integrated molecular analysis of adult T cell leukemia/lymphoma

  Nature Genetics · 2015 · 10.1038/ng.3415

• Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

  Cell Metabolism · 2014 · 10.1016/j.cmet.2014.03.017

• Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

  Nature Genetics · 2014 · 10.1038/ng.2984

• Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

  Nature Genetics · 2014 · 10.1038/ng.3126

• Integrated molecular analysis of clear-cell renal cell carcinoma

  Nature Genetics · 2013 · 10.1038/ng.2699

• Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

  Leukemia · 2013 · https://doi.org/10.1038/leu.2013.336

• Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

  Science · 2013 · https://doi.org/10.1126/science.1239947

• Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

  Cancer Cell · 2012 · 10.1016/j.ccr.2012.05.016

• Cohesin mediates transcriptional insulation by CCCTC-binding factor

  Nature · 2008 · 10.1038/nature06634

• The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

  Nature Cell Biology · 2008 · 10.1038/ncb1794

• BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation

  Journal of Biological Chemistry · 2008 · 10.1074/jbc.m801774200

• Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

  Oncogene · 2007 · 10.1038/sj.onc.1210251

• Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

  Nature · 2007 · https://doi.org/10.1038/nature05945

• Global variation in copy number in the human genome

  Nature · 2006 · https://doi.org/10.1038/nature05329

• Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

  Nature Cell Biology · 2006 · 10.1038/ncb1507

• Copy number variation: New insights in genome diversity

  Genome Research · 2006 · 10.1101/gr.3677206

• Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m400674200

• Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m313973200

• A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

  Nature · 1997 · 10.1038/386292a0

• Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member

  Cell · 1992 · https://doi.org/10.1016/0092-8674(92)90154-5

Current projects

No projects listed.