Juan C. Sáez

Research interests

Publications

• Hunting for connexin hemichannels

  FEBS Letters · 2014 · 10.1016/j.febslet.2014.03.004

• Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

  Frontiers in Pharmacology · 2013 · 10.3389/fphar.2013.00088

• Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

  The FASEB Journal · 2012 · 10.1096/fj.11-198416

• Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

  Brain Research · 2012 · 10.1016/j.brainres.2012.08.042

• Amyloid β-Induced Death in Neurons Involves Glial and Neuronal Hemichannels

  Journal of Neuroscience · 2011 · 10.1523/jneurosci.6417-10.2011

• ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

  Journal of Neurochemistry · 2011 · 10.1111/j.1471-4159.2011.07210.x

• Cell membrane permeabilization via connexin hemichannels in living and dying cells

  Experimental Cell Research · 2010 · 10.1016/j.yexcr.2010.05.026

• Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

  Antioxidants and Redox Signaling · 2008 · 10.1089/ars.2008.2130

• Cx43 Hemichannels and Gap Junction Channels in Astrocytes Are Regulated Oppositely by Proinflammatory Cytokines Released from Activated Microglia

  Journal of Neuroscience · 2007 · 10.1523/jneurosci.2042-07.2007

• S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0511118103

• Connexin-based gap junction hemichannels: Gating mechanisms

  Biochimica et Biophysica Acta (BBA) - Biomembranes · 2005 · 10.1016/j.bbamem.2005.01.014

• Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue

  Brain Research Reviews · 2004 · 10.1016/j.brainresrev.2004.08.002

• Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions

  Physiological Reviews · 2003 · https://doi.org/10.1152/physrev.00007.2003

• Gating and regulation of connexin 43 (Cx43) hemichannels

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.1434298100

• New roles for astrocytes: Gap junction hemichannels have something to communicate

  Trends in Neurosciences · 2003 · 10.1016/j.tins.2003.09.008

• TNF-α Plus IFN-γ Induce Connexin43 Expression and Formation of Gap Junctions Between Human Monocytes/Macrophages That Enhance Physiological Responses

  The Journal of Immunology · 2003 · 10.4049/jimmunol.170.3.1320

• Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

  Proceedings of the National Academy of Sciences · 2001 · https://doi.org/10.1073/pnas.012589799

• Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-γ and tumor necrosis factor-α

  Proceedings of the National Academy of Sciences · 2001 · 10.1073/pnas.051634298

• Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.

  Circulation Research · 1994 · 10.1161/01.res.74.6.1050

• Cell-, age- and stage-dependent distribution of connexin43 gap junctions in testes

  Journal of Cell Science · 1992 · 10.1242/jcs.103.1.81

• Gap junctions: New tools, new answers, new questions

  Neuron · 1991 · https://doi.org/10.1016/0896-6273(91)90241-q

• Phosphorylation of connexin 32, a hepatocyte gap‐junction protein, by cAMP‐dependent protein kinase, protein kinase C and Ca2+/calmodulin‐dependent protein kinase II

  European Journal of Biochemistry · 1990 · 10.1111/j.1432-1033.1990.tb19223.x

• Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

  Proceedings of the National Academy of Sciences · 1989 · https://doi.org/10.1073/pnas.86.8.2708

• Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures.

  The Journal of Cell Biology · 1987 · 10.1083/jcb.105.1.541

• cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.

  Proceedings of the National Academy of Sciences · 1986 · 10.1073/pnas.83.8.2473

Current projects

No projects listed.