Toshimasa Yamauchi

Research interests

Publications

• A cross-population atlas of genetic associations for 220 human phenotypes

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00931-x

• Role of Insulin Resistance in MAFLD

  International Journal of Molecular Sciences · 2021 · 10.3390/ijms22084156

• Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0640-3

• Identification of type 2 diabetes loci in 433,540 East Asian individuals

  Nature · 2020 · 10.1038/s41586-020-2263-3

• Preparation and culture of bone marrow-derived macrophages from mice for functional analysis

  STAR Protocols · 2020 · 10.1016/j.xpro.2020.100246

• A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

  Nature · 2013 · https://doi.org/10.1038/nature12656

• Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

  Cell Metabolism · 2013 · 10.1016/j.cmet.2013.01.001

• Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

  Nature · 2010 · https://doi.org/10.1038/nature08991

• Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

  Cell Metabolism · 2007 · 10.1016/j.cmet.2007.06.003

• Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

  Nature Medicine · 2007 · https://doi.org/10.1038/nm1557

• Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome

  Diabetes Care · 2006 · 10.2337/dc05-1801

• Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m601284200

• Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

  Cell Metabolism · 2005 · 10.1016/j.cmet.2004.11.005

• Adiponectin and Adiponectin Receptors

  Endocrine Reviews · 2005 · https://doi.org/10.1210/er.2005-0005

• Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m402367200

• Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m209033200

• Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m300365200

• Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

  Nature · 2003 · https://doi.org/10.1038/nature01705

• Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population

  Diabetes · 2002 · 10.2337/diabetes.51.2.536

• Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

  Nature Medicine · 2002 · https://doi.org/10.1038/nm788

• Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.c200251200

• The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m103241200

• The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

  Nature Medicine · 2001 · https://doi.org/10.1038/90984

• Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

  Diabetes · 2000 · 10.2337/diabetes.49.11.1880

• PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

  Molecular Cell · 1999 · 10.1016/s1097-2765(00)80210-5

Current projects

No projects listed.