Tom Mikkelsen

Research interests

Publications

• Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma

  JAMA Oncology · 2022 · https://doi.org/10.1001/jamaoncol.2022.5370

• First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

  Journal of Translational Medicine · 2018 · 10.1186/s12967-018-1507-6

• Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

  Neuro-Oncology · 2018 · https://doi.org/10.1093/neuonc/noy075

• Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.06.003

• Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma

  Science Translational Medicine · 2016 · https://doi.org/10.1126/scitranslmed.aad9784

• New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.01.015

• Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

  Cell · 2016 · https://doi.org/10.1016/j.cell.2015.12.028

• Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2015.65.7825

• The integrated landscape of driver genomic alterations in glioblastoma

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2734

• Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma

  Journal of Clinical Oncology · 2013 · 10.1200/jco.2012.47.2464

• The Somatic Genomic Landscape of Glioblastoma

  Cell · 2013 · https://doi.org/10.1016/j.cell.2013.09.034

• Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

  Science · 2012 · 10.1126/science.1220834

• Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

  Cancer Cell · 2012 · 10.1016/j.ccr.2012.08.024

• Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1114033109

• Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

  Journal of Clinical Oncology · 2010 · 10.1200/jco.2009.26.3541

• The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline

  Journal of Neuro-Oncology · 2009 · 10.1007/s11060-009-0073-4

• Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

  Journal of Clinical Oncology · 2009 · 10.1200/jco.2008.19.8721

• Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme

  Journal of Clinical Oncology · 2008 · 10.1200/jco.2008.16.7510

• Altered adenosine-to-inosine RNA editing in human cancer

  Genome Research · 2007 · https://doi.org/10.1101/gr.6493107

• Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

  Cancer Cell · 2006 · 10.1016/j.ccr.2006.03.003

• Clonal expansion of p53 mutant cells is associated with brain tumour progression

  Nature · 1992 · 10.1038/355846a0

Current projects

No projects listed.