Christian G. Hartinger

Research interests

Publications

• A Reduced‐Symmetry Heterobimetallic [PdPtL4]4+ Cage: Assembly, Guest Binding, and Stimulus‐Induced Switching

  Angewandte Chemie International Edition · 2020 · https://doi.org/10.1002/anie.202003220

• Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

  Chemical Society Reviews · 2017 · https://doi.org/10.1039/c7cs00332c

• The development of RAPTA compounds for the treatment of tumors

  Coordination Chemistry Reviews · 2015 · https://doi.org/10.1016/j.ccr.2015.06.014

• Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications

  Journal of Organometallic Chemistry · 2013 · https://doi.org/10.1016/j.jorganchem.2013.09.016

• Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

  Organometallics · 2012 · https://doi.org/10.1021/om300373t

• A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

  Chemistry - A European Journal · 2011 · https://doi.org/10.1002/chem.201100298

• Anticancer Activity of Metal Complexes: Involvement of Redox Processes

  Antioxidants and Redox Signaling · 2011 · https://doi.org/10.1089/ars.2010.3663

• Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity

  Journal of Medicinal Chemistry · 2009 · https://doi.org/10.1021/jm8013234

• Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

  Anti-Cancer Drugs · 2009 · https://doi.org/10.1097/cad.0b013e328322fbc5

• Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

  Journal of Medicinal Chemistry · 2008 · https://doi.org/10.1021/jm8006678

• Bioorganometallic chemistry—from teaching paradigms to medicinal applications

  Chemical Society Reviews · 2008 · https://doi.org/10.1039/b707077m

• Resistance against novel anticancer metal compounds: Differences and similarities

  Drug Resistance Updates · 2008 · https://doi.org/10.1016/j.drup.2008.02.002

• The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways

  JBIC Journal of Biological Inorganic Chemistry · 2008 · https://doi.org/10.1007/s00775-008-0400-9

• Influence of the Spacer Length on the in Vitro Anticancer Activity of Dinuclear Ruthenium−Arene Compounds

  Organometallics · 2008 · https://doi.org/10.1021/om800207t

• KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

  Chemistry & Biodiversity · 2008 · https://doi.org/10.1002/cbdv.200890195

• Antitumour metal compounds: more than theme and variations

  Dalton Transactions · 2007 · https://doi.org/10.1039/b712656p

• Structure−Activity Relationships for NAMI-A-type Complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole): Aquation, Redox Properties, Protein Binding, and Antiproliferative Activity

  Journal of Medicinal Chemistry · 2007 · https://doi.org/10.1021/jm061081y

• Gold(III) compounds as anticancer agents: Relevance of gold–protein interactions for their mechanism of action

  Journal of Inorganic Biochemistry · 2007 · https://doi.org/10.1016/j.jinorgbio.2007.11.003

• From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)

  Journal of Inorganic Biochemistry · 2006 · https://doi.org/10.1016/j.jinorgbio.2006.02.013

• Redox behavior of tumor-inhibiting ruthenium( iii ) complexes and effects of physiological reductants on their binding to GMP

  Dalton Transactions · 2006 · https://doi.org/10.1039/b511792e

• Interactions of Antitumor Metallodrugs with Serum Proteins: Advances in Characterization Using Modern Analytical Methodology

  Chemical Reviews · 2006 · https://doi.org/10.1021/cr040704h

• Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy

  Journal of Analytical Atomic Spectrometry · 2004 · https://doi.org/10.1039/b309160k

Current projects

No projects listed.