Michael Houghton

Research interests

Publications

• Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

  The Journal of Experimental Medicine · 2003 · https://doi.org/10.1084/jem.20030239

• The Outcome of Hepatitis C Virus Infection Is Predicted by Escape Mutations in Epitopes Targeted by Cytotoxic T Lymphocytes

  Immunity · 2001 · https://doi.org/10.1016/s1074-7613(01)00245-x

• Global surveillance and control of hepatitis C

  UCL Discovery (University College London) · 1999

• Analysis of a Successful Immune Response against Hepatitis C Virus

  Immunity · 1999 · https://doi.org/10.1016/s1074-7613(00)80044-8

• Binding of Hepatitis C Virus to CD81

  Science · 1998 · https://doi.org/10.1126/science.282.5390.938

• Liver-Derived CTL in Hepatitis C Virus Infection: Breadth and Specificity of Responses in a Cohort of Persons with Chronic Infection

  The Journal of Immunology · 1998 · https://doi.org/10.4049/jimmunol.160.3.1479

• The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C

  The Journal of Immunology · 1997 · https://doi.org/10.4049/jimmunol.158.3.1473

• Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

  Journal of Clinical Investigation · 1996 · https://doi.org/10.1172/jci118842

• A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells.

  Proceedings of the National Academy of Sciences · 1996 · https://doi.org/10.1073/pnas.93.5.1759

• HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.

  Journal of Clinical Investigation · 1995 · https://doi.org/10.1172/jci118287

• Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

  Proceedings of the National Academy of Sciences · 1995 · https://doi.org/10.1073/pnas.92.7.2755

• Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

  Journal of Clinical Investigation · 1995 · https://doi.org/10.1172/jci117694

• A proposed system for the nomenclature of hepatitis C viral genotypes

  Hepatology · 1994 · https://doi.org/10.1002/hep.1840190538

• Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis

  The Journal of Immunology · 1992 · https://doi.org/10.4049/jimmunol.149.10.3339

• Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease

  Hepatology · 1991 · https://doi.org/10.1002/hep.1840140227

• Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

  Virology · 1991 · https://doi.org/10.1016/0042-6822(91)90104-j

• Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay

  The Lancet · 1991 · https://doi.org/10.1016/0140-6736(91)90942-i

• Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.

  Proceedings of the National Academy of Sciences · 1991 · https://doi.org/10.1073/pnas.88.5.1711

• Hepatitis C virus: The major causative agent of viral non-A, non-B hepatitis

  British Medical Bulletin · 1990 · https://doi.org/10.1093/oxfordjournals.bmb.a072408

• Detection of Antibody to Hepatitis C Virus in Prospectively Followed Transfusion Recipients with Acute and Chronic Non-A, Non-B Hepatitis

  New England Journal of Medicine · 1989 · https://doi.org/10.1056/nejm198911303212202

• HEPATITIS C VIRUS ANTIBODIES AMONG RISK GROUPS IN SPAIN

  The Lancet · 1989 · https://doi.org/10.1016/s0140-6736(89)90485-6

• Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

  Science · 1989 · https://doi.org/10.1126/science.2523562

• An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

  Science · 1989 · https://doi.org/10.1126/science.2496467

• PREVALENCE OF ANTIBODIES TO HEPATITIS C VIRUS IN ITALIAN PATIENTS WITH HEPATOCELLULAR CARCINOMA

  The Lancet · 1989 · https://doi.org/10.1016/s0140-6736(89)91016-7

• Structure, sequence and expression of the hepatitis delta (δ) viral genome

  Nature · 1986 · https://doi.org/10.1038/323508a0

Current projects

No projects listed.