François Ghiringhelli

Research interests

Publications

• Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study

  The Lancet · 2023 · https://doi.org/10.1016/s0140-6736(23)00772-9

• Five-Year Outcomes of FOLFIRINOX vs Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

  JAMA Oncology · 2022 · https://doi.org/10.1001/jamaoncol.2022.3829

• Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

  Nature Medicine · 2022 · 10.1038/s41591-021-01655-5

• Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

  Science · 2020 · https://doi.org/10.1126/science.aax0701

• Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

  Science · 2017 · https://doi.org/10.1126/science.aan3706

• The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

  Nature Immunology · 2015 · 10.1038/ni.3202

• Classification of current anticancer immunotherapies

  Oncotarget · 2014 · https://doi.org/10.18632/oncotarget.2998

• Consensus guidelines for the detection of immunogenic cell death

  OncoImmunology · 2014 · https://doi.org/10.4161/21624011.2014.955691

• The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

  Science · 2013 · https://doi.org/10.1126/science.1240537

• An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

  Science · 2012 · https://doi.org/10.1126/science.1224922

• Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

  Nature Medicine · 2012 · 10.1038/nm.2999

• Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

  Science Translational Medicine · 2012 · https://doi.org/10.1126/scitranslmed.3003807

• Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

  Science · 2011 · https://doi.org/10.1126/science.1208347

• Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

  The Journal of Experimental Medicine · 2011 · https://doi.org/10.1084/jem.20100269

• Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

  Journal of Clinical Investigation · 2010 · https://doi.org/10.1172/jci40483

• 5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

  Cancer Research · 2010 · 10.1158/0008-5472.can-09-3690

• Immunogenic death of colon cancer cells treated with oxaliplatin

  Oncogene · 2009 · 10.1038/onc.2009.356

• Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

  Nature Medicine · 2009 · 10.1038/nm.2028

• The anticancer immune response: indispensable for therapeutic success?

  Journal of Clinical Investigation · 2008 · 10.1172/jci35180

• The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

  Immunological Reviews · 2007 · https://doi.org/10.1111/j.1600-065x.2007.00573.x

• Molecular characteristics of immunogenic cancer cell death

  Cell Death and Differentiation · 2007 · 10.1038/sj.cdd.4402269

• Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

  Nature Medicine · 2007 · 10.1038/nm1622

• Immunological aspects of cancer chemotherapy

  Nature reviews. Immunology · 2007 · 10.1038/nri2216

• Calreticulin exposure dictates the immunogenicity of cancer cell death

  Nature Medicine · 2006 · 10.1038/nm1523

• Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

  Cancer Immunology Immunotherapy · 2006 · 10.1007/s00262-006-0225-8

• Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4 + CD25 + regulatory T cell proliferation

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20050463

• Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20050915

• CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20051511

• CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

  European Journal of Immunology · 2004 · 10.1002/eji.200324181

Current projects

No projects listed.