Carlos López-Otı́n

Research interests

Publications

• Hallmarks of aging: An expanding universe

  Cell · 2023 · https://doi.org/10.1016/j.cell.2022.11.001

• Autophagy in major human diseases

  The EMBO Journal · 2021 · https://doi.org/10.15252/embj.2021108863

• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  Cell Death and Differentiation · 2018 · https://doi.org/10.1038/s41418-017-0012-4

• Molecular definitions of autophagy and related processes

  The EMBO Journal · 2017 · https://doi.org/10.15252/embj.201796697

• Metabolic Control of Longevity

  Cell · 2016 · 10.1016/j.cell.2016.07.031

• A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms10815

• Non-coding recurrent mutations in chronic lymphocytic leukaemia

  Nature · 2015 · https://doi.org/10.1038/nature14666

• ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

  Cell Reports · 2014 · https://doi.org/10.1016/j.celrep.2014.06.018

• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

  Cell Death and Differentiation · 2014 · 10.1038/cdd.2014.137

• Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

  Molecular Cell · 2014 · https://doi.org/10.1016/j.molcel.2014.01.016

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

  Science · 2013 · 10.1126/science.1230381

• The Hallmarks of Aging

  Cell · 2013 · https://doi.org/10.1016/j.cell.2013.05.039

• An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

  Science · 2012 · https://doi.org/10.1126/science.1224922

• Comparative and demographic analysis of orang-utan genomes

  Nature · 2011 · 10.1038/nature09687

• Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

  Nature Genetics · 2011 · 10.1038/ng.1032

• Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

  The Journal of Cell Biology · 2011 · https://doi.org/10.1083/jcb.201008167

• Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

  Nature · 2011 · 10.1038/nature10113

• The genome of a songbird

  Nature · 2010 · 10.1038/nature08819

• Proteases: Multifunctional Enzymes in Life and Disease

  Journal of Biological Chemistry · 2008 · 10.1074/jbc.r800035200

• Increased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8)

  The FASEB Journal · 2007 · https://doi.org/10.1096/fj.06-7860com

• Emerging roles of proteases in tumour suppression

  Nature reviews. Cancer · 2007 · 10.1038/nrc2228

• Human and mouse proteases: a comparative genomic approach

  Nature Reviews Genetics · 2003 · 10.1038/nrg1111

• Protease degradomics: A new challenge for proteomics

  Nature Reviews Molecular Cell Biology · 2002 · 10.1038/nrm858

• Strategies for MMP inhibition in cancer: innovations for the post-trial era

  Nature reviews. Cancer · 2002 · 10.1038/nrc884

• Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

  Journal of Biological Chemistry · 1996 · 10.1074/jbc.271.29.17124

• Biochemical Characterization of Human Collagenase-3

  Journal of Biological Chemistry · 1996 · 10.1074/jbc.271.3.1544

• Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

  Journal of Biological Chemistry · 1994 · 10.1016/s0021-9258(19)89457-7

Current projects

No projects listed.