Salem Chouaı̈b

Research interests

Publications

• Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies

  Frontiers in Immunology · 2021 · 10.3389/fimmu.2020.613114

• CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17

  Cell Reports Medicine · 2020 · https://doi.org/10.1016/j.xcrm.2020.100127

• Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

  Cells · 2019 · 10.3390/cells8091083

• Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

  Frontiers in Immunology · 2018 · https://doi.org/10.3389/fimmu.2018.00414

• The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

  OncoImmunology · 2017 · https://doi.org/10.1080/2162402x.2016.1263412

• New insights into the role of EMT in tumor immune escape

  Molecular Oncology · 2017 · https://doi.org/10.1002/1878-0261.12093

• Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

  Proceedings of the National Academy of Sciences · 2017 · https://doi.org/10.1073/pnas.1703921114

• Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

  Oncogene · 2016 · https://doi.org/10.1038/onc.2016.225

• Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

  OncoImmunology · 2015 · https://doi.org/10.1080/2162402x.2015.1062968

• Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

  American Journal of Physiology-Cell Physiology · 2015 · https://doi.org/10.1152/ajpcell.00207.2015

• Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status

  European Urology · 2015 · 10.1016/j.eururo.2015.11.029

• PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

  The Journal of Experimental Medicine · 2014 · https://doi.org/10.1084/jem.20131916

• Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis

  Cancer Research · 2013 · https://doi.org/10.1158/0008-5472.can-12-2432

• Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1304790110

• Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape

  Frontiers in Immunology · 2012 · 10.3389/fimmu.2012.00021

• Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells

  Cancer Research · 2012 · 10.1158/0008-5472.can-12-1383

• Tumor-Associated Macrophages (TAMs) Form an Interconnected Cellular Supportive Network in Anaplastic Thyroid Carcinoma

  PLoS ONE · 2011 · 10.1371/journal.pone.0022567

• Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

  Cancer Research · 2011 · https://doi.org/10.1158/0008-5472.can-11-1094

• The Cooperative Induction of Hypoxia-Inducible Factor-1α and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis

  The Journal of Immunology · 2009 · 10.4049/jimmunol.0800854

• Microglia-derived TGF-β as an important regulator of glioblastoma invasion—an inhibition of TGF-β-dependent effects by shRNA against human TGF-β type II receptor

  Oncogene · 2007 · https://doi.org/10.1038/sj.onc.1210683

• αEβ7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis

  The Journal of Experimental Medicine · 2007 · https://doi.org/10.1084/jem.20061524

• Phosphostim-Activated γδ T Cells Kill Autologous Metastatic Renal Cell Carcinoma

  The Journal of Immunology · 2005 · 10.4049/jimmunol.174.3.1338

• Prostaglandin E2 acts at two distinct pathways of T lymphocyte activation: inhibition of interleukin 2 production and down-regulation of transferrin receptor expression.

  The Journal of Immunology · 1985 · https://doi.org/10.4049/jimmunol.135.2.1172

• The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes.

  The Journal of Immunology · 1984 · 10.4049/jimmunol.132.4.1851

• The mechanism of inhibition of human IL 2 production.

  The Journal of Immunology · 1982 · 10.4049/jimmunol.129.6.2463

Current projects

No projects listed.