Lois E. Shepherd

Research interests

Publications

• Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer

  New England Journal of Medicine · 2024 · 10.1056/nejmoa2308900

• Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

  The Lancet · 2019 · 10.1016/s0140-6736(18)33137-4

• Randomized Comparison of Gemcitabine, Dexamethasone, and Cisplatin Versus Dexamethasone, Cytarabine, and Cisplatin Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed and Refractory Aggressive Lymphomas: NCIC-CTG LY.12

  Journal of Clinical Oncology · 2014 · 10.1200/jco.2013.53.9593

• Exemestane Versus Anastrozole in Postmenopausal Women With Early Breast Cancer: NCIC CTG MA.27—A Randomized Controlled Phase III Trial

  Journal of Clinical Oncology · 2013 · 10.1200/jco.2012.44.7805

• A 50-Gene Intrinsic Subtype Classifier for Prognosis and Prediction of Benefit from Adjuvant Tamoxifen

  Clinical Cancer Research · 2012 · 10.1158/1078-0432.ccr-12-0286

• CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group

  The Lancet Oncology · 2011 · https://doi.org/10.1016/s1470-2045(11)70235-2

• ABVD Alone versus Radiation-Based Therapy in Limited-Stage Hodgkin's Lymphoma

  New England Journal of Medicine · 2011 · 10.1056/nejmoa1111961

• Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial

  The Lancet Oncology · 2009 · https://doi.org/10.1016/s1470-2045(09)70314-6

• Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer

  Clinical Cancer Research · 2008 · 10.1158/1078-0432.ccr-07-1489

• K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer

  New England Journal of Medicine · 2008 · https://doi.org/10.1056/nejmoa0804385

• Effect of Letrozole Versus Placebo on Bone Mineral Density in Women With Primary Breast Cancer Completing 5 or More Years of Adjuvant Tamoxifen: A Companion Study to NCIC CTG MA.17

  Journal of Clinical Oncology · 2006 · 10.1200/jco.2005.05.4882

• HER2 and Responsiveness of Breast Cancer to Adjuvant Chemotherapy

  New England Journal of Medicine · 2006 · 10.1056/nejmoa054504

• Assessment of Quality of Life in MA.17: A Randomized, Placebo-Controlled Trial of Letrozole After 5 Years of Tamoxifen in Postmenopausal Women

  Journal of Clinical Oncology · 2005 · 10.1200/jco.2005.11.181

• Randomized Trial of Letrozole Following Tamoxifen as Extended Adjuvant Therapy in Receptor-Positive Breast Cancer: Updated Findings from NCIC CTG MA.17

  JNCI Journal of the National Cancer Institute · 2005 · https://doi.org/10.1093/jnci/dji250

• Randomized Comparison of ABVD Chemotherapy With a Strategy That Includes Radiation Therapy in Patients With Limited-Stage Hodgkin’s Lymphoma: National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group

  Journal of Clinical Oncology · 2005 · 10.1200/jco.2005.09.085

• Pooled Analysis of Fluorouracil-Based Adjuvant Therapy for Stage II and III Colon Cancer: Who Benefits and by How Much?

  Journal of Clinical Oncology · 2004 · 10.1200/jco.2004.09.059

• A Randomized Trial of Letrozole in Postmenopausal Women After Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer

  Obstetrical & Gynecological Survey · 2004 · 10.1097/01.ogx.0000115858.45890.53

• Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

  New England Journal of Medicine · 2003 · 10.1056/nejmoa022289

• A Randomized Trial of Letrozole in Postmenopausal Women after Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer

  New England Journal of Medicine · 2003 · https://doi.org/10.1056/nejmoa032312

• A Pooled Analysis of Adjuvant Chemotherapy for Resected Colon Cancer in Elderly Patients

  New England Journal of Medicine · 2001 · 10.1056/nejmoa010957

• Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.

  PubMed · 2000 · 10.1182/blood.v95.1.90

• Fludarabine Compared with Chlorambucil as Primary Therapy for Chronic Lymphocytic Leukemia

  New England Journal of Medicine · 2000 · 10.1056/nejm200012143432402

• Randomized trial of intensive cyclophosphamide, epirubicin, and fluorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer. National Cancer Institute of Canada Clinical Trials Group.

  Journal of Clinical Oncology · 1998 · 10.1200/jco.1998.16.8.2651

• Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer.

  Journal of Clinical Oncology · 1998 · 10.1200/jco.1998.16.1.295

• All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

  New England Journal of Medicine · 1997 · 10.1056/nejm199710093371501

Current projects

No projects listed.