Dae‐Sik Lim

Research interests

Publications

• YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

  Journal of Clinical Investigation · 2017 · https://doi.org/10.1172/jci93825

• LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms11961

• Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

  Cell Reports · 2015 · https://doi.org/10.1016/j.celrep.2015.03.015

• Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

  Nature Cell Biology · 2015 · https://doi.org/10.1038/ncb3111

• A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms4315

• SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage

  Cell Reports · 2013 · https://doi.org/10.1016/j.celrep.2013.05.029

• Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

  PLoS Genetics · 2013 · https://doi.org/10.1371/journal.pgen.1003380

• cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

  The EMBO Journal · 2013 · https://doi.org/10.1038/emboj.2013.102

• Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

  Nature Medicine · 2013 · https://doi.org/10.1038/nm.3322

• The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

  Proceedings of the National Academy of Sciences · 2010 · https://doi.org/10.1073/pnas.0912203107

• ER71 Acts Downstream of BMP, Notch, and Wnt Signaling in Blood and Vessel Progenitor Specification

  Cell stem cell · 2008 · https://doi.org/10.1016/j.stem.2008.03.008

• A crucial role of WW45 in developing epithelial tissues in the mouse

  The EMBO Journal · 2008 · https://doi.org/10.1038/emboj.2008.63

• Role of the Tumor Suppressor RASSF1A in Mst1-Mediated Apoptosis

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-05-2951

• The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex

  Nature Cell Biology · 2004 · https://doi.org/10.1038/ncb1091

• Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation

  Molecular and Cellular Biology · 2002 · https://doi.org/10.1128/mcb.22.4.1049-1059.2002

• ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

  Nature · 2000 · https://doi.org/10.1038/35007091

• The many substrates and functions of ATM

  Nature Reviews Molecular Cell Biology · 2000 · https://doi.org/10.1038/35043058

• Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

  Journal of Biological Chemistry · 1999 · https://doi.org/10.1074/jbc.274.53.37538

• Deletion of Ku86 causes early onset of senescence in mice

  Proceedings of the National Academy of Sciences · 1999 · https://doi.org/10.1073/pnas.96.19.10770

• Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c

  Journal of Biological Chemistry · 1999 · https://doi.org/10.1074/jbc.274.30.21155

• ATM binds to β-adaptin in cytoplasmic vesicles

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.17.10146

• Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

  Science · 1998 · https://doi.org/10.1126/science.281.5383.1677

• Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

  Nature · 1997 · https://doi.org/10.1038/386804a0

• Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

  Cell · 1996 · https://doi.org/10.1016/s0092-8674(00)80111-7

• A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

  Molecular and Cellular Biology · 1996 · https://doi.org/10.1128/mcb.16.12.7133

Current projects

No projects listed.