George P. Patrinos

Research interests

Publications

• Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living

  Human Genomics · 2023 · 10.1186/s40246-023-00561-w

• A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

  The Lancet · 2023 · 10.1016/s0140-6736(22)01841-4

• Clinically relevant updates of the HbVar database of human hemoglobin variants and thalassemia mutations

  Nucleic Acids Research · 2020 · 10.1093/nar/gkaa959

• Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity

  Human Genomics · 2020 · 10.1186/s40246-020-00290-4

• Rethinking Drug Repositioning and Development with Artificial Intelligence, Machine Learning, and Omics

  OMICS A Journal of Integrative Biology · 2019 · 10.1089/omi.2019.0151

• Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping

  The American Journal of Human Genetics · 2017 · 10.1016/j.ajhg.2017.07.012

• Medical education in pharmacogenomics—results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx)

  European Journal of Clinical Pharmacology · 2017 · 10.1007/s00228-017-2292-5

• Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

  Blood · 2016 · 10.1182/blood-2016-01-694331

• Computational approaches in target identification and drug discovery

  Computational and Structural Biotechnology Journal · 2016 · 10.1016/j.csbj.2016.04.004

• A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics

  PLoS ONE · 2016 · 10.1371/journal.pone.0162866

• Global implementation of genomic medicine: We are not alone

  Science Translational Medicine · 2015 · 10.1126/scitranslmed.aab0194

• RD-Connect: An Integrated Platform Connecting Databases, Registries, Biobanks and Clinical Bioinformatics for Rare Disease Research

  Journal of General Internal Medicine · 2014 · 10.1007/s11606-014-2908-8

• Personalized Pharmacogenomics Profiling Using Whole-Genome Sequencing

  Pharmacogenomics · 2014 · 10.2217/pgs.14.102

• Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene

  Nature Genetics · 2013 · 10.1038/ng.2745

• Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

  Nucleic Acids Research · 2013 · 10.1093/nar/gkt911

• Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

  Nature Genetics · 2011 · 10.1038/ng.785

• Genomic rearrangements in inherited disease and cancer

  Seminars in Cancer Biology · 2010 · 10.1016/j.semcancer.2010.05.007

• Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

  Nature Genetics · 2010 · 10.1038/ng.630

• Realities and Expectations of Pharmacogenomics and Personalized Medicine: Impact of Translating Genetic Knowledge into Clinical Practice

  Pharmacogenomics · 2010 · 10.2217/pgs.10.97

• Gene conversion: mechanisms, evolution and human disease

  Nature Reviews Genetics · 2007 · https://doi.org/10.1038/nrg2193

• HbVar database of human hemoglobin variants and thalassemia mutations: 2007 update

  Human Mutation · 2007 · 10.1002/humu.9479

• Multiple interactions between regulatory regions are required to stabilize an active chromatin hub

  Genes & Development · 2004 · 10.1101/gad.289704

• Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies

  Nucleic Acids Research · 2003 · 10.1093/nar/gkh006

• DNA hypermethylation: when tumour suppressor genes go silent

  Human Genetics · 2002 · 10.1007/s00439-002-0783-6

• HbVar: A relational database of human hemoglobin variants and thalassemia mutations at the globin gene server

  Human Mutation · 2002 · 10.1002/humu.10044

Current projects

No projects listed.