Frank Brombacher

Research interests

Publications

• Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4316

• Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.08.006

• FANTOM5 CAGE profiles of human and mouse samples

  Scientific Data · 2017 · https://doi.org/10.1038/sdata.2017.112

• Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

  Science · 2015 · https://doi.org/10.1126/science.1259418

• Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

  Proceedings of the National Academy of Sciences · 2014 · https://doi.org/10.1073/pnas.1312717110

• Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

  Nature Communications · 2013 · https://doi.org/10.1038/ncomms2877

• IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

  The Journal of Experimental Medicine · 2013 · https://doi.org/10.1084/jem.20121999

• Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

  Nature · 2011 · https://doi.org/10.1038/nature10653

• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.375

• IL-25 regulates Th17 function in autoimmune inflammation

  The Journal of Experimental Medicine · 2007 · https://doi.org/10.1084/jem.20061738

• Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

  Nature · 2007 · https://doi.org/10.1038/nature05894

• Interleukin-17 is a negative regulator of established allergic asthma

  The Journal of Experimental Medicine · 2006 · https://doi.org/10.1084/jem.20061401

• Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

  Journal of Clinical Investigation · 2006 · https://doi.org/10.1172/jci28828

• Alternative Macrophage Activation Is Essential for Survival during Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology

  Immunity · 2004 · https://doi.org/10.1016/s1074-7613(04)00107-4

• Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages

  Journal of Leukocyte Biology · 2002 · https://doi.org/10.1189/jlb.71.4.597

• Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies

  Science · 1999 · https://doi.org/10.1126/science.286.5447.2156

• Aluminium Hydroxide Adjuvant Initiates Strong Antigen-Specific Th2 Responses in the Absence of IL-4- or IL-13-Mediated Signaling

  The Journal of Immunology · 1999 · https://doi.org/10.4049/jimmunol.163.12.6448

• Requirement for IL-13 Independently of IL-4 in Experimental Asthma

  Science · 1998 · https://doi.org/10.1126/science.282.5397.2261

• An interleukin 4 (IL-4)-independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice

  Proceedings of the National Academy of Sciences · 1997 · https://doi.org/10.1073/pnas.94.20.10838

• IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

  Immunity · 1996 · https://doi.org/10.1016/s1074-7613(00)80294-0

Current projects

No projects listed.