Alain Colige

Research interests

Publications

• Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer

  Breast Cancer Research · 2019 · 10.1186/s13058-018-1095-7

• Loss of ADAMTS3 activity causes Hennekam lymphangiectasia–lymphedema syndrome 3

  Human Molecular Genetics · 2017 · 10.1093/hmg/ddx297

• Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF‐β signaling as primary targets

  The FASEB Journal · 2016 · 10.1096/fj.15-279869

• ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

  Angiogenesis · 2015 · 10.1007/s10456-015-9488-z

• The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology

  Matrix Biology · 2015 · 10.1016/j.matbio.2015.04.001

• 18F-FDG Uptake Assessed by PET/CT in Abdominal Aortic Aneurysms Is Associated with Cellular and Molecular Alterations Prefacing Wall Deterioration and Rupture

  Journal of Nuclear Medicine · 2013 · 10.2967/jnumed.112.115873

• MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells

  PLoS ONE · 2011 · 10.1371/journal.pone.0016979

• MicroRNAs Profiling in Murine Models of Acute and Chronic Asthma: A Relationship with mRNAs Targets

  PLoS ONE · 2011 · 10.1371/journal.pone.0016509

• Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration

  Biomacromolecules · 2011 · 10.1021/bm200680q

• New asthma biomarkers: lessons from murine models of acute and chronic asthma

  American Journal of Physiology-Lung Cellular and Molecular Physiology · 2008 · 10.1152/ajplung.90367.2008

• Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis

  Development · 2006 · 10.1242/dev.02308

• Mutations Near Amino End of α1(I) Collagen Cause Combined Osteogenesis Imperfecta/Ehlers-Danlos Syndrome by Interference with N-propeptide Processing

  Journal of Biological Chemistry · 2005 · 10.1074/jbc.m414698200

• Histone deacetylase HDAC8 associates with smooth muscle α‐actin and is essential for smooth muscle cell contractility

  The FASEB Journal · 2005 · 10.1096/fj.04-2303fje

• Acidic Extracellular pH Induces Matrix Metalloproteinase-9 Expression in Mouse Metastatic Melanoma Cells through the Phospholipase D-Mitogen-activated Protein Kinase Signaling

  Journal of Biological Chemistry · 2005 · 10.1074/jbc.m411313200

• Domains and Maturation Processes That Regulate the Activity of ADAMTS-2, a Metalloproteinase Cleaving the Aminopropeptide of Fibrillar Procollagens Types I–III and V

  Journal of Biological Chemistry · 2005 · 10.1074/jbc.m506458200

• Novel Types of Mutation Responsible for the Dermatosparactic Type of Ehlers–Danlos Syndrome (Type VIIC) and Common Polymorphisms in the ADAMTS2 Gene

  Journal of Investigative Dermatology · 2004 · 10.1111/j.0022-202x.2004.23406.x

• Expression Pattern of Metalloproteinases and Tissue Inhibitors of Matrix-Metalloproteinases in Cycling Human Endometrium1

  Biology of Reproduction · 2003 · 10.1095/biolreprod.103.015933

• Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

  Oncogene · 2002 · https://doi.org/10.1038/sj.onc.1205108

• Cloning and Characterization of ADAMTS-14, a Novel ADAMTS Displaying High Homology with ADAMTS-2 and ADAMTS-3

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m105601200

• Modulation of Adipose Tissue Expression of Murine Matrix Metalloproteinases and Their Tissue Inhibitors With Obesity

  Diabetes · 2002 · 10.2337/diabetes.51.4.1093

• Topically Applied Vitamin C Enhances the mRNA Level of Collagens I and III, Their Processing Enzymes and Tissue Inhibitor of Matrix Metalloproteinase 1 in the Human Dermis11Part of this work was presented in poster form at the American Academy of Dermatology, San Francisco, CA, March 10–15, 2000.

  Journal of Investigative Dermatology · 2001 · 10.1046/j.0022-202x.2001.01362.x

• Procollagen II Amino Propeptide Processing by ADAMTS-3

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m103466200

• Human Ehlers-Danlos Syndrome Type VII C and Bovine Dermatosparaxis Are Caused by Mutations in the Procollagen I N-Proteinase Gene

  The American Journal of Human Genetics · 1999 · https://doi.org/10.1086/302504

• cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.6.2374

• Mutation analysis of coding sequences for type I procollagen in individuals with low bone density

  Journal of Bone and Mineral Research · 1994 · 10.1002/jbmr.5650090618

Current projects

No projects listed.