Jalees Rehman

Research interests

Publications

• Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy

  Redox Biology · 2022 · https://doi.org/10.1016/j.redox.2022.102304

• mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

  Immunity · 2020 · https://doi.org/10.1016/j.immuni.2020.02.002

• IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

  Journal of Clinical Investigation · 2020 · https://doi.org/10.1172/jci136908

• Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

  eLife · 2020 · https://doi.org/10.7554/elife.51413

• Vascular dysfunction—The disregarded partner of Alzheimer's disease

  Alzheimer s & Dementia · 2019 · https://doi.org/10.1016/j.jalz.2018.07.222

• Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

  Proceedings of the National Academy of Sciences · 2019 · https://doi.org/10.1073/pnas.1902165116

• The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

  Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.04.032

• Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.05.054

• Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

  Journal of Clinical Investigation · 2017 · https://doi.org/10.1172/jci94495

• Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.10.006

• Endothelial progenitor cells and vascular repair

  Current Opinion in Hematology · 2014 · https://doi.org/10.1097/moh.0000000000000041

• Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells

  PLoS ONE · 2013 · https://doi.org/10.1371/journal.pone.0077077

• Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

  Circulation Research · 2012 · https://doi.org/10.1161/circresaha.111.263848

• Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

  The FASEB Journal · 2012 · https://doi.org/10.1096/fj.11-196543

• Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle

  Journal of Molecular Medicine · 2011 · https://doi.org/10.1007/s00109-011-0804-9

• A Central Role for CD68(+) Macrophages in Hepatopulmonary Syndrome: Reversal by Macrophage Depletion

  American Journal of Respiratory and Critical Care Medicine · 2010 · https://doi.org/10.1164/rccm.201008-1303oc

• Empowering self-renewal and differentiation: the role of mitochondria in stem cells

  Journal of Molecular Medicine · 2010 · https://doi.org/10.1007/s00109-010-0678-2

• Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

  Circulation · 2010 · https://doi.org/10.1161/circulationaha.109.916098

• The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

  Journal of Molecular Medicine · 2009 · https://doi.org/10.1007/s00109-009-0524-6

• Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells

  Journal of the American College of Cardiology · 2004 · https://doi.org/10.1016/j.jacc.2004.02.049

• Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells

  Circulation · 2004 · https://doi.org/10.1161/01.cir.0000121425.42966.f1

• Peripheral Blood “Endothelial Progenitor Cells” Are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors

  Circulation · 2003 · https://doi.org/10.1161/01.cir.0000058702.69484.a0

• Obesity is associated with increased levels of circulating hepatocyte growth factor

  Journal of the American College of Cardiology · 2003 · https://doi.org/10.1016/s0735-1097(03)00231-6

Current projects

No projects listed.