Manuel A. Friese

Research interests

Publications

• CD19-targeted chimeric antigen receptor T cell therapy in two patients with multiple sclerosis

  Med · 2024 · 10.1016/j.medj.2024.03.002

• Ferroptosis in health and disease

  Redox Biology · 2024 · 10.1016/j.redox.2024.103211

• The neuropathobiology of multiple sclerosis

  Nature reviews. Neuroscience · 2024 · 10.1038/s41583-024-00823-z

• STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

  Cell · 2024 · 10.1016/j.cell.2024.05.031

• The immunology of multiple sclerosis

  Nature reviews. Immunology · 2022 · 10.1038/s41577-022-00718-z

• The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

  Stem Cell Reports · 2022 · 10.1016/j.stemcr.2021.12.011

• Rituximab Treatment and Long-term Outcome of Patients With Autoimmune Encephalitis

  Neurology Neuroimmunology & Neuroinflammation · 2021 · 10.1212/nxi.0000000000001088

• Frequent neurocognitive deficits after recovery from mild COVID-19

  Brain Communications · 2020 · 10.1093/braincomms/fcaa205

• Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

  Immunity · 2019 · 10.1016/j.immuni.2018.12.010

• A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

  Acta Neuropathologica · 2019 · https://doi.org/10.1007/s00401-019-02026-8

• Neuronal vulnerability and multilineage diversity in multiple sclerosis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1404-z

• Immunopathology of multiple sclerosis

  Nature reviews. Immunology · 2015 · https://doi.org/10.1038/nri3871

• A vaccine targeting mutant IDH1 induces antitumour immunity

  Nature · 2014 · https://doi.org/10.1038/nature13387

• Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

  Nature Reviews Neurology · 2014 · 10.1038/nrneurol.2014.37

• TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

  Nature Medicine · 2012 · 10.1038/nm.3015

• Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

  Blood · 2012 · 10.1182/blood-2012-02-412726

• Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

  Brain · 2011 · 10.1093/brain/awq337

• N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes

  Brain · 2010 · https://doi.org/10.1093/brain/awq113

• T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides

  Immunity · 2009 · 10.1016/j.immuni.2009.01.009

• Pathogenic CD8+ T cells in multiple sclerosis

  Annals of Neurology · 2009 · 10.1002/ana.21744

• Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

  Nature Medicine · 2008 · 10.1038/nm.1881

• Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

  American Journal Of Pathology · 2007 · https://doi.org/10.2353/ajpath.2008.070690

• Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

  Nature Medicine · 2007 · 10.1038/nm1668

• Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

  Brain · 2005 · 10.1093/brain/awh578

• RNA Interference Targeting Transforming Growth Factor-β Enhances NKG2D-Mediated Antiglioma Immune Response, Inhibits Glioma Cell Migration and Invasiveness, and Abrogates Tumorigenicity In vivo

  Cancer Research · 2004 · 10.1158/0008-5472.can-04-1627

• MICA/NKG2D-mediated immunogene therapy of experimental gliomas.

  PubMed · 2003

Current projects

No projects listed.