Ke Ding

Research interests

Publications

• Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis

  Cell Death and Disease · 2022 · 10.1038/s41419-022-04966-8

• Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors

  Journal of Medicinal Chemistry · 2021 · 10.1021/acs.jmedchem.1c01719

• 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells

  Journal of the American Chemical Society · 2020 · 10.1021/jacs.9b12116

• Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

  Molecular Cancer · 2020 · 10.1186/s12943-020-01202-9

• Functions of dopamine in plants: a review

  Plant Signaling & Behavior · 2020 · 10.1080/15592324.2020.1827782

• New Promise and Opportunities for Allosteric Kinase Inhibitors

  Angewandte Chemie International Edition · 2019 · 10.1002/anie.201914525

• Targeting EGFR L858R/T790M and EGFR L858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry

  Medicinal Research Reviews · 2018 · 10.1002/med.21488

• Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

  Cell chemical biology · 2017 · 10.1016/j.chembiol.2017.10.010

• Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

  Nature Medicine · 2016 · 10.1038/nm.4041

• Crystalline Si/Graphene Quantum Dots Heterojunction Solar Cells

  The Journal of Physical Chemistry C · 2014 · 10.1021/jp412591k

• Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors

  Journal of Medicinal Chemistry · 2013 · 10.1021/jm301824k

• Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

  癌症：英文版 · 2013 · 10.5732/cjc.012.10285

• Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region–Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib

  Journal of Medicinal Chemistry · 2013 · 10.1021/jm301581y

• Magnetically engineered Cd-free quantum dots as dual-modality probes for fluorescence/magnetic resonance imaging of tumors

  Biomaterials · 2013 · 10.1016/j.biomaterials.2013.10.078

• Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

  癌症：英文版 · 2012 · 10.5732/cjc.011.10290

• Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

  Journal of Medicinal Chemistry · 2012 · 10.1021/jm2013503

• Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in Macrophages through a Positive Feedback Loop Involving c-Jun NH2-terminal Kinases and Activator Protein-1

  Journal of Biological Chemistry · 2010 · 10.1074/jbc.m109.097907

• Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

  ACS Medicinal Chemistry Letters · 2010 · 10.1021/ml100146z

• Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF-κB Pathway and Generation of Reactive Oxygen Species

  Cancer Research · 2010 · 10.1158/0008-5472.can-09-3950

• BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

  Cell Research · 2010 · 10.1038/cr.2010.172

• (2-Pyridyl)acetone-Promoted Cu-Catalyzed O-Arylation of Phenols with Aryl Iodides, Bromides, and Chlorides

  The Journal of Organic Chemistry · 2009 · 10.1021/jo9012157

• Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

  Journal of Medicinal Chemistry · 2009 · 10.1021/jm901400z

• Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0708917105

• Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

  Journal of Medicinal Chemistry · 2006 · 10.1021/jm051122a

• Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

  Journal of the American Chemical Society · 2005 · 10.1021/ja051147z

Current projects

No projects listed.