Takashi Kadowaki

Research interests

Publications

• Definition and diagnostic criteria of clinical obesity

  The Lancet Diabetes & Endocrinology · 2025 · https://doi.org/10.1016/s2213-8587(24)00316-4

• A cross-population atlas of genetic associations for 220 human phenotypes

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00931-x

• Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0640-3

• A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

  Nature · 2013 · https://doi.org/10.1038/nature12656

• Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus

  Journal of Diabetes Investigation · 2010 · 10.1111/j.2040-1124.2010.00074.x

• Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

  Nature · 2010 · https://doi.org/10.1038/nature08991

• Diabetes in Asia

  JAMA · 2009 · 10.1001/jama.2009.726

• CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

  Nature Medicine · 2009 · 10.1038/nm.1964

• Cardiovascular Disease and Risk Factors in Asia

  Circulation · 2008 · 10.1161/circulationaha.108.790048

• Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

  Nature Genetics · 2008 · 10.1038/ng.207

• Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

  Cell Metabolism · 2007 · 10.1016/j.cmet.2007.06.003

• Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

  Nature Medicine · 2007 · 10.1038/nm1557

• Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m601284200

• International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

  Pharmacological Reviews · 2006 · 10.1124/pr.58.4.5

• Adiponectin and Adiponectin Receptors

  Endocrine Reviews · 2005 · https://doi.org/10.1210/er.2005-0005

• PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

  Journal of Clinical Investigation · 2004 · 10.1172/jci19900

• Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m300365200

• Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

  Nature · 2003 · https://doi.org/10.1038/nature01705

• Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m209033200

• Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

  Nature Medicine · 2002 · https://doi.org/10.1038/nm788

• Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.c200251200

• Report of the Committee on the classification and diagnostic criteria of diabetes mellitus

  Diabetes Research and Clinical Practice · 2002 · 10.1016/s0168-8227(01)00365-5

• The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

  Nature Medicine · 2001 · https://doi.org/10.1038/90984

• Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

  Genes & Development · 2001 · 10.1101/gad.913901

• PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

  Molecular Cell · 1999 · 10.1016/s1097-2765(00)80210-5

• Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

  Journal of Clinical Investigation · 1998 · 10.1172/jci1235

• Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

  Nature · 1994 · 10.1038/372182a0

Current projects

No projects listed.