Nicola Waddell

Research interests

Publications

• Deep learning in cancer diagnosis, prognosis and treatment selection

  Genome Medicine · 2021 · 10.1186/s13073-021-00968-x

• Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

  Nature Genetics · 2020 · 10.1038/s41588-019-0564-y

• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0576-7

• Genomic footprints of activated telomere maintenance mechanisms in cancer

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13824-9

• Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity

  Cancer Discovery · 2019 · 10.1158/2159-8290.cd-19-0541

• MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

  Immunity · 2019 · 10.1016/j.immuni.2019.08.011

• CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

  Nature Communications · 2019 · 10.1038/s41467-019-10968-6

• Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

  Nature Communications · 2019 · 10.1038/s41467-019-11107-x

• Whole-genome landscapes of major melanoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22071

• A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment

  Cancer Research · 2017 · 10.1158/0008-5472.can-17-2826

• Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

  Nature Immunology · 2017 · 10.1038/ni.3800

• Hypermutation In Pancreatic Cancer

  Gastroenterology · 2016 · 10.1053/j.gastro.2016.09.060

• Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

  Nature Genetics · 2016 · 10.1038/ng.3659

• Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant

  The American Journal of Human Genetics · 2016 · 10.1016/j.ajhg.2016.03.001

• Hypermutation In Pancreatic Cancer

  Gastroenterology · 2016 · 10.1053/j.gastro.2016.09.060

• Hypermutation In Pancreatic Cancer

  Gastroenterology · 2016 · 10.1053/j.gastro.2016.09.060

• Hypermutation In Pancreatic Cancer

  Gastroenterology · 2016 · 10.1053/j.gastro.2016.09.060

• Hypermutation In Pancreatic Cancer

  Gastroenterology · 2016 · 10.1053/j.gastro.2016.09.060

• Hypermutation In Pancreatic Cancer

  Gastroenterology · 2016 · 10.1053/j.gastro.2016.09.060

• Whole–genome characterization of chemoresistant ovarian cancer

  Nature · 2015 · https://doi.org/10.1038/nature14410

• A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

  Nature Communications · 2015 · 10.1038/ncomms10001

• Whole genomes redefine the mutational landscape of pancreatic cancer

  Nature · 2015 · https://doi.org/10.1038/nature14169

• Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling

  International Journal of Cancer · 2014 · 10.1002/ijc.28765

• Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling

  International Journal of Cancer · 2014 · 10.1002/ijc.28765

• Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling

  International Journal of Cancer · 2014 · 10.1002/ijc.28765

• Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

  Nature Communications · 2014 · 10.1038/ncomms6224

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

  Nature · 2012 · 10.1038/nature11547

• Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1202490109

• Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1202490109

• Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1202490109

• PINA v2.0: mining interactome modules

  Nucleic Acids Research · 2011 · 10.1093/nar/gkr967

• MicroRNAs and their isomiRs function cooperatively to target common biological pathways

  Genome biology · 2011 · 10.1186/gb-2011-12-12-r126

• RAD51 135G→C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies

  The American Journal of Human Genetics · 2007 · https://doi.org/10.1086/522611

Current projects

No projects listed.