Rolf Backofen

Research interests

Publications

• Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine

  Nature Neuroscience · 2022 · 10.1038/s41593-022-01027-3

• pyGenomeTracks: reproducible plots for multivariate genomic datasets

  Bioinformatics · 2020 · 10.1093/bioinformatics/btaa692

• Galaxy HiCExplorer 3: a web server for reproducible Hi-C, capture Hi-C and single-cell Hi-C data analysis, quality control and visualization

  Nucleic Acids Research · 2020 · 10.1093/nar/gkaa220

• A pan-cancer analysis of synonymous mutations

  Nature Communications · 2019 · 10.1038/s41467-019-10489-2

• Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

  Nature Reviews Microbiology · 2019 · https://doi.org/10.1038/s41579-019-0299-x

• Community-Driven Data Analysis Training for Biology

  Cell Systems · 2018 · 10.1016/j.cels.2018.05.012

• Galaxy HiCExplorer: a web server for reproducible Hi-C data analysis, quality control and visualization

  Nucleic Acids Research · 2018 · 10.1093/nar/gky504

• Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

  Nature Communications · 2018 · 10.1038/s41467-017-02762-z

• Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

  Nature Genetics · 2018 · 10.1038/s41588-018-0120-1

• IntaRNA 2.0: enhanced and customizable prediction of RNA–RNA interactions

  Nucleic Acids Research · 2017 · https://doi.org/10.1093/nar/gkx279

• DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

  Nature · 2017 · 10.1038/nature21715

• Global RNA recognition patterns of post‐transcriptional regulators Hfq and CsrA revealed by UV crosslinking in vivo

  The EMBO Journal · 2016 · 10.15252/embj.201593360

• The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression

  Nature Communications · 2016 · 10.1038/ncomms12791

• An updated evolutionary classification of CRISPR–Cas systems

  Nature Reviews Microbiology · 2015 · https://doi.org/10.1038/nrmicro3569

• GraphProt: modeling binding preferences of RNA-binding proteins

  Genome biology · 2014 · 10.1186/gb-2014-15-1-r17

• CopraRNA and IntaRNA: predicting small RNA targets, networks and interaction domains

  Nucleic Acids Research · 2014 · 10.1093/nar/gku359

• Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

  Nature Medicine · 2014 · https://doi.org/10.1038/nm.3746

• Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

  Nature Communications · 2014 · 10.1038/ncomms6288

• Comparative genomics boosts target prediction for bacterial small RNAs

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1303248110

• LocARNA-P: Accurate boundary prediction and improved detection of structural RNAs

  RNA · 2012 · 10.1261/rna.029041.111

• Freiburg RNA Tools: a web server integrating INTARNA, EXPARNA and LOCARNA

  Nucleic Acids Research · 2010 · 10.1093/nar/gkq316

• IntaRNA: efficient prediction of bacterial sRNA targets incorporating target site accessibility and seed regions

  Bioinformatics · 2008 · 10.1093/bioinformatics/btn544

• Pre-mRNA Secondary Structures Influence Exon Recognition

  PLoS Genetics · 2007 · 10.1371/journal.pgen.0030204

• Inferring Noncoding RNA Families and Classes by Means of Genome-Scale Structure-Based Clustering

  PLoS Computational Biology · 2007 · 10.1371/journal.pcbi.0030065

• Inferring Non-Coding RNA Families and Classes by Means of Genome-Scale Structure-Based Clustering

  PLoS Computational Biology · 2005 · 10.1371/journal.pcbi.0030065.eor

Current projects

No projects listed.