Paul C. Boutros

Research interests

Publications

• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.03.009

• A clinically applicable integrative molecular classification of meningiomas

  Nature · 2021 · 10.1038/s41586-021-03850-3

• Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression

  Nature Cell Biology · 2021 · 10.1038/s41556-020-00613-6

• Divergent mutational processes distinguish hypoxic and normoxic tumours

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14052-x

• The evolutionary history of 2,658 cancers

  Nature · 2020 · https://doi.org/10.1038/s41586-019-1907-7

• Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0562-0

• A robust benchmark for detection of germline large deletions and insertions

  Nature Biotechnology · 2020 · 10.1038/s41587-020-0538-8

• The DNA methylation landscape of advanced prostate cancer

  Nature Genetics · 2020 · 10.1038/s41588-020-0648-8

• A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13825-8

• Integrative pathway enrichment analysis of multivariate omics data

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13983-9

• The repertoire of mutational signatures in human cancer

  Nature · 2020 · https://doi.org/10.1038/s41586-020-1943-3

• Widespread and Functional RNA Circularization in Localized Prostate Cancer

  Cell · 2019 · 10.1016/j.cell.2019.01.025

• Molecular landmarks of tumor hypoxia across cancer types

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-018-0318-2

• Best practices for benchmarking germline small-variant calls in human genomes

  Nature Biotechnology · 2019 · 10.1038/s41587-019-0054-x

• Genomic hallmarks of localized, non-indolent prostate cancer

  Nature · 2017 · 10.1038/nature20788

• The Molecular Taxonomy of Primary Prostate Cancer

  Cell · 2015 · 10.1016/j.cell.2015.10.025

• Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

  Nature Genetics · 2015 · 10.1038/ng.3221

• Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection

  Nature Methods · 2015 · 10.1038/nmeth.3407

• Pathway and network analysis of cancer genomes

  Nature Methods · 2015 · 10.1038/nmeth.3440

• Spatial genomic heterogeneity within localized, multifocal prostate cancer

  Nature Genetics · 2015 · 10.1038/ng.3315

• Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study

  The Lancet Oncology · 2014 · 10.1016/s1470-2045(14)71021-6

• Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies

  The Lancet Oncology · 2013 · 10.1016/s1470-2045(13)70045-7

• Predicting outcomes in radiation oncology—multifactorial decision support systems

  Nature Reviews Clinical Oncology · 2012 · 10.1038/nrclinonc.2012.196

• VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R

  BMC Bioinformatics · 2011 · 10.1186/1471-2105-12-35

• Dysregulation of the mevalonate pathway promotes transformation

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.0910258107

• The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis

  Cancer Research · 2006 · 10.1158/0008-5472.can-06-0037

• Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries

  Molecular Pharmacology · 2005 · 10.1124/mol.105.018705

Current projects

No projects listed.