Nahum Sonenberg

Research interests

Publications

• Fragile X syndrome

  Nature Reviews Disease Primers · 2017 · 10.1038/nrdp.2017.65

• Translational control by 5′-untranslated regions of eukaryotic mRNAs

  Science · 2016 · 10.1126/science.aad9868

• Targeting the translation machinery in cancer

  Nature Reviews Drug Discovery · 2015 · 10.1038/nrd4505

• mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

  Cell Metabolism · 2013 · https://doi.org/10.1016/j.cmet.2013.10.001

• Pharmacological brake-release of mRNA translation enhances cognitive memory

  eLife · 2013 · https://doi.org/10.7554/elife.00498

• The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

  Nature Structural & Molecular Biology · 2012 · 10.1038/nsmb.2296

• Regulation of mRNA Translation and Stability by microRNAs

  Annual Review of Biochemistry · 2010 · https://doi.org/10.1146/annurev-biochem-060308-103103

• Translational Control of Long-Lasting Synaptic Plasticity and Memory

  Neuron · 2009 · 10.1016/j.neuron.2008.10.055

• Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

  Cell · 2009 · https://doi.org/10.1016/j.cell.2009.01.042

• Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

  Nature Reviews Genetics · 2008 · https://doi.org/10.1038/nrg2290

• Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-2310

• RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation

  Journal of Biological Chemistry · 2007 · 10.1074/jbc.m700906200

• Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

  Cancer Research · 2006 · 10.1158/0008-5472.can-06-1500

• Translational control in stress and apoptosis

  Nature Reviews Molecular Cell Biology · 2005 · 10.1038/nrm1618

• Regulation of cap-dependent translation by eIF4E inhibitory proteins

  Nature · 2005 · 10.1038/nature03205

• Upstream and downstream of mTOR

  Genes & Development · 2004 · 10.1101/gad.1212704

• XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

  Immunity · 2004 · 10.1016/j.immuni.2004.06.010

• Hierarchical phosphorylation of the translation inhibitor 4E-BP1

  Genes & Development · 2001 · 10.1101/gad.912401

• Regulation of translation initiation by FRAP/mTOR

  Genes & Development · 2001 · 10.1101/gad.887201

• Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

  Nature Medicine · 2000 · 10.1038/77558

• Translational control of gene expression

  Medical Entomology and Zoology · 2000

• eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

  Annual Review of Biochemistry · 1999 · 10.1146/annurev.biochem.68.1.913

• Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

  Genes & Development · 1999 · 10.1101/gad.13.11.1422

• 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

  Genes & Development · 1998 · 10.1101/gad.12.4.502

• Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

  Nature · 1994 · 10.1038/371762a0

• Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

  Nature · 1988 · 10.1038/334320a0

Current projects

No projects listed.