Paola Di Meglio

Research interests

Publications

• Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

  Nature Genetics · 2022 · 10.1038/s41588-021-00969-x

• Factors associated with adverse COVID-19 outcomes in patients with psoriasis—insights from a global registry–based study

  Journal of Allergy and Clinical Immunology · 2020 · 10.1016/j.jaci.2020.10.007

• HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis

  Journal of Allergy and Clinical Immunology · 2018 · 10.1016/j.jaci.2018.11.038

• An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target

  Science Translational Medicine · 2017 · 10.1126/scitranslmed.aan2514

• AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production

  Journal of Investigative Dermatology · 2016 · 10.1016/j.jid.2016.06.618

• The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.02.046

• Psoriasis

  Cold Spring Harbor Perspectives in Medicine · 2014 · https://doi.org/10.1101/cshperspect.a015354

• The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

  Annual Review of Immunology · 2014 · https://doi.org/10.1146/annurev-immunol-032713-120245

• Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions

  Immunity · 2014 · https://doi.org/10.1016/j.immuni.2014.04.019

• Differential methylation of the TRPA1 promoter in pain sensitivity

  Nature Communications · 2014 · 10.1038/ncomms3978

• Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis

  Journal of Investigative Dermatology · 2013 · https://doi.org/10.1038/jid.2013.477

• Gene expression changes with age in skin, adipose tissue, blood and brain

  Genome biology · 2013 · https://doi.org/10.1186/gb-2013-14-7-r75

• Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

  The American Journal of Human Genetics · 2013 · https://doi.org/10.1016/j.ajhg.2013.10.004

• Mapping cis- and trans-regulatory effects across multiple tissues in twins

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2394

• Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

  The Journal of Experimental Medicine · 2012 · https://doi.org/10.1084/jem.20112583

• The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

  PLoS ONE · 2011 · https://doi.org/10.1371/journal.pone.0017160

• Psoriasis

  Annual Review of Pathology Mechanisms of Disease · 2011 · https://doi.org/10.1146/annurev-pathol-011811-132448

• The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study

  PLoS Genetics · 2011 · https://doi.org/10.1371/journal.pgen.1002003

• Identification of a Novel Proinflammatory Human Skin-Homing Vγ9Vδ2 T Cell Subset with a Potential Role in Psoriasis

  The Journal of Immunology · 2011 · https://doi.org/10.4049/jimmunol.1100804

• Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis

  The American Journal of Human Genetics · 2011 · https://doi.org/10.1016/j.ajhg.2011.07.022

• The Multitasking Organ: Recent Insights into Skin Immune Function

  Immunity · 2011 · https://doi.org/10.1016/j.immuni.2011.12.003

• Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

  The Journal of Immunology · 2010 · 10.4049/jimmunol.1001538

• Skin immune sentinels in health and disease

  Nature reviews. Immunology · 2009 · https://doi.org/10.1038/nri2622

• The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

  Journal of Investigative Dermatology · 2009 · https://doi.org/10.1038/jid.2009.59

• Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis

  Human Genetics · 2007 · https://doi.org/10.1007/s00439-007-0397-0

Current projects

No projects listed.