Thomas Efferth

Research interests

Publications

• Natural products in drug discovery: advances and opportunities

  Nature Reviews Drug Discovery · 2021 · https://doi.org/10.1038/s41573-020-00114-z

• Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

  Drug Resistance Updates · 2020 · https://doi.org/10.1016/j.drup.2020.100715

• Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

  Medicinal Research Reviews · 2020 · 10.1002/med.21743

• Best practice in research – Overcoming common challenges in phytopharmacological research

  Journal of Ethnopharmacology · 2019 · https://doi.org/10.1016/j.jep.2019.112230

• Biotechnology Applications of Plant Callus Cultures

  Engineering · 2018 · https://doi.org/10.1016/j.eng.2018.11.006

• Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2)

  Breast Cancer Research and Treatment · 2017 · https://doi.org/10.1007/s10549-017-4261-1

• Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

  Pharmacological Research · 2017 · 10.1016/j.phrs.2017.11.030

• From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

  Seminars in Cancer Biology · 2017 · https://doi.org/10.1016/j.semcancer.2017.02.009

• The role of p53 in cancer drug resistance and targeted chemotherapy

  Oncotarget · 2016 · https://doi.org/10.18632/oncotarget.13475

• Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

  Pharmacological Research · 2016 · 10.1016/j.phrs.2016.06.018

• Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

  Phytomedicine · 2015 · https://doi.org/10.1016/j.phymed.2015.08.002

• Kaempferol Derivatives as Antiviral Drugs against the 3a Channel Protein of Coronavirus

  Planta Medica · 2014 · 10.1055/s-0033-1360277

• Activities of Ten Essential Oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 Cancer Cells

  Molecules · 2010 · 10.3390/molecules15053200

• Cameroonian Medicinal Plants: Pharmacology and Derived Natural Products

  Frontiers in Pharmacology · 2010 · 10.3389/fphar.2010.00123

• Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy

  Current Drug Targets · 2010 · https://doi.org/10.2174/138945011793591626

• Supercritical carbon dioxide extraction of seed oil from yellow horn (Xanthoceras sorbifolia Bunge.) and its anti-oxidant activity

  Bioresource Technology · 2009 · https://doi.org/10.1016/j.biortech.2009.11.082

• Rapid microwave-assisted transesterification of yellow horn oil to biodiesel using a heteropolyacid solid catalyst

  Bioresource Technology · 2009 · https://doi.org/10.1016/j.biortech.2009.08.069

• Enzyme assisted extraction of luteolin and apigenin from pigeonpea [Cajanuscajan (L.) Millsp.] leaves

  Food Chemistry · 2008 · https://doi.org/10.1016/j.foodchem.2008.04.003

• The Antiviral Activities of Artemisinin and Artesunate

  Clinical Infectious Diseases · 2008 · https://doi.org/10.1086/591195

• Antimicrobial activity of clove and rosemary essential oils alone and in combination

  Phytotherapy Research · 2007 · https://doi.org/10.1002/ptr.2179

• From traditional Chinese medicine to rational cancer therapy

  Trends in Molecular Medicine · 2007 · https://doi.org/10.1016/j.molmed.2007.07.001

• Molecular Target-Guided Tumor Therapy with Natural Products Derived from Traditional Chinese Medicine

  Current Medicinal Chemistry · 2007 · https://doi.org/10.2174/092986707781368441

• Chemotherapy-induced resistance by ATP-binding cassette transporter genes

  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · 2007 · 10.1016/j.bbcan.2007.05.002

• Willmar Schwabe Award 2006: Antiplasmodial and Antitumor Activity of Artemisinin - From Bench to Bedside

  Planta Medica · 2007 · 10.1055/s-2007-967138

• Artesunate Induces ROS-Mediated Apoptosis in Doxorubicin-Resistant T Leukemia Cells

  PLoS ONE · 2007 · 10.1371/journal.pone.0000693

• Optimization of luteolin separation from pigeonpea [Cajanus cajan (L.) Millsp.] leaves by macroporous resins

  Journal of Chromatography A · 2006 · https://doi.org/10.1016/j.chroma.2006.08.067

• Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells

  Current Drug Targets · 2006 · 10.2174/138945006776359412

• Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron

  Free Radical Biology and Medicine · 2004 · 10.1016/j.freeradbiomed.2004.06.023

• Molecular Modes of Action of Artesunate in Tumor Cell Lines

  Molecular Pharmacology · 2003 · https://doi.org/10.1124/mol.64.2.382

• The anti-malarial artesunate is also active against cancer

  International Journal of Oncology · 2001 · https://doi.org/10.3892/ijo.18.4.767

Current projects

No projects listed.