Sunil R. Lakhani

Research interests

Publications

• Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

  Annals of Oncology · 2022 · https://doi.org/10.1016/j.annonc.2022.09.159

• Adjuvant Olaparib for Patients with BRCA1 - or BRCA2 -Mutated Breast Cancer

  New England Journal of Medicine · 2021 · https://doi.org/10.1056/nejmoa2105215

• Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

  npj Breast Cancer · 2020 · https://doi.org/10.1038/s41523-020-0156-0

• The 2019 World Health Organization classification of tumours of the breast

  Histopathology · 2020 · https://doi.org/10.1111/his.14091

• Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update

  Journal of Clinical Oncology · 2020 · https://doi.org/10.1200/jco.19.02309

• The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers in breast cancer clinical trials and daily practice

  The Journal of Pathology · 2020 · https://doi.org/10.1002/path.5406

• Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update

  Archives of Pathology & Laboratory Medicine · 2020 · https://doi.org/10.5858/arpa.2019-0904-sa

• Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research

  Advances in Anatomic Pathology · 2017 · https://doi.org/10.1097/pap.0000000000000162

• Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourina

  Advances in Anatomic Pathology · 2017 · https://doi.org/10.1097/pap.0000000000000161

• Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

  Advances in Anatomic Pathology · 2017 · 10.1097/pap.0000000000000161

• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

  Nature Medicine · 2017 · 10.1038/nm.4292

• Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group

  Modern Pathology · 2016 · https://doi.org/10.1038/modpathol.2016.109

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · https://doi.org/10.1038/nature17676

• Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant

  The American Journal of Human Genetics · 2016 · https://doi.org/10.1016/j.ajhg.2016.03.001

• Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group

  Modern Pathology · 2016 · https://doi.org/10.1038/modpathol.2016.109

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · https://doi.org/10.1038/nature11017

• Rare variants in the ATMgene and risk of breast cancer

  Breast Cancer Research · 2011 · https://doi.org/10.1186/bcr2919

• Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

  Modern Pathology · 2010 · 10.1038/modpathol.2010.200

• Breast cancer prognostic classification in the molecular era: the role of histological grade

  Breast Cancer Research · 2010 · 10.1186/bcr2607

• FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas

  Clinical Cancer Research · 2006 · https://doi.org/10.1158/1078-0432.ccr-06-1164

• Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

  Clinical Cancer Research · 2005 · 10.1158/1078-0432.ccr-04-2424

• Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS)

  The Lancet · 2005 · 10.1016/s0140-6736(05)66481-1

• A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

  Nature Genetics · 2005 · https://doi.org/10.1038/ng1571

• Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

  Cancer Research · 2005 · https://doi.org/10.1158/0008-5472.can-05-1855

• Pathology of Ovarian Cancers in BRCA1 and BRCA2 Carriers

  Clinical Cancer Research · 2004 · https://doi.org/10.1158/1078-0432.ccr-1029-3

Current projects

No projects listed.