Lisa M. Coussens

Research interests

Publications

• Early detection of cancer

  Science · 2022 · 10.1126/science.aay9040

• The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.03.053

• Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

  Cancer Cell · 2019 · 10.1016/j.ccell.2019.02.009

• Macrophages and Metabolism in the Tumor Microenvironment

  Cell Metabolism · 2019 · https://doi.org/10.1016/j.cmet.2019.06.001

• Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

  Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.06.006

• Understanding the tumor immune microenvironment (TIME) for effective therapy

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0014-x

• Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

  Cell Reports · 2017 · 10.1016/j.celrep.2017.03.037

• Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

  Science · 2017 · https://doi.org/10.1126/science.aan4236

• Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

  Nature Nanotechnology · 2016 · 10.1038/nnano.2016.168

• Macrophages and Therapeutic Resistance in Cancer

  Cancer Cell · 2015 · 10.1016/j.ccell.2015.02.015

• Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

  Cancer Cell · 2014 · 10.1016/j.ccell.2014.09.006

• Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

  Science · 2013 · 10.1126/science.1232227

• Differential macrophage programming in the tumor microenvironment

  Trends in Immunology · 2012 · 10.1016/j.it.2011.12.001

• Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

  Cancer Cell · 2012 · 10.1016/j.ccr.2012.02.022

• Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

  Cancer Discovery · 2011 · 10.1158/2159-8274.cd-10-0028

• CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

  Cancer Cell · 2009 · 10.1016/j.ccr.2009.06.018

• TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT

  Annual Review of Pathology Mechanisms of Disease · 2006 · 10.1146/annurev.pathol.1.110304.100224

• Paradoxical roles of the immune system during cancer development

  Nature reviews. Cancer · 2006 · 10.1038/nrc1782

• Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

  Science · 2002 · 10.1126/science.1067100

• Inflammation and cancer

  Nature · 2002 · 10.1038/nature01322

• MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

  Cell · 2000 · 10.1016/s0092-8674(00)00139-2

• Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

  Genes & Development · 1999 · 10.1101/gad.13.11.1382

• Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

  The EMBO Journal · 1987 · 10.1002/j.1460-2075.1987.tb02655.x

• The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

  Science · 1986 · 10.1126/science.3755547

• Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

  Science · 1986 · 10.1126/science.3755548

• Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

  Science · 1985 · 10.1126/science.2999974

• Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

  Nature · 1985 · 10.1038/313756a0

• Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

  Nature · 1984 · 10.1038/309418a0

Current projects

No projects listed.