Kenneth G. C. Smith

Research interests

Publications

• Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

  Immunity · 2021 · 10.1016/j.immuni.2021.05.010

• Single-cell multi-omics analysis of the immune response in COVID-19

  Nature Medicine · 2021 · 10.1038/s41591-021-01329-2

• A thermostable, closed SARS-CoV-2 spike protein trimer

  Nature Structural & Molecular Biology · 2020 · 10.1038/s41594-020-0478-5

• Analysis of the B cell receptor repertoire in six immune-mediated diseases

  Nature · 2019 · 10.1038/s41586-019-1595-3

• Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

  Nature Genetics · 2017 · 10.1038/ng.3755

• T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

  Nature · 2015 · 10.1038/nature14468

• A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

  Diabetes · 2014 · 10.2337/db13-1777

• Genetically Distinct Subsets within ANCA-Associated Vasculitis

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1108735

• Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

  Journal of Clinical Investigation · 2011 · 10.1172/jci59255

• Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

  Journal of Clinical Investigation · 2011 · 10.1172/jci57834

• Foxp3+ follicular regulatory T cells control the germinal center response

  Nature Medicine · 2011 · https://doi.org/10.1038/nm.2425

• A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

  Nature Medicine · 2010 · 10.1038/nm.2130

• FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications

  Nature reviews. Immunology · 2010 · 10.1038/nri2762

• A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody–associated vasculitis

  Arthritis & Rheumatism · 2009 · 10.1002/art.24637

• Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

  Nature · 2008 · https://doi.org/10.1038/nature06890

• microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells

  Immunity · 2007 · 10.1016/j.immuni.2007.10.009

• Competence and competition: the challenge of becoming a long-lived plasma cell

  Nature reviews. Immunology · 2006 · https://doi.org/10.1038/nri1886

• Long‐term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse, and re‐treatment

  Arthritis & Rheumatism · 2006 · 10.1002/art.22046

• Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

  Nature Medicine · 2005 · 10.1038/nm1288

• CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

  Transplantation · 1999 · 10.1097/00007890-199911270-00032

• Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients

  The Lancet · 1998 · 10.1016/s0140-6736(05)77739-4

• The extent of affinity maturation differs between the memory and antibody‐forming cell compartments in the primary immune response

  The EMBO Journal · 1997 · 10.1093/emboj/16.11.2996

• The phenotype and fate of the antibody‐forming cells of the splenic foci

  European Journal of Immunology · 1996 · 10.1002/eji.1830260226

• Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

  Nature · 1995 · 10.1038/375331a0

• Standards for grading texture of erosional topography

  American Journal of Science · 1950 · https://doi.org/10.2475/ajs.248.9.655

Current projects

No projects listed.