Paul J. Young

Research interests

Publications

• Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

  New England Journal of Medicine · 2022 · https://doi.org/10.1056/nejmoa2200644

• Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis

  NEJM Evidence · 2022 · 10.1056/evidoa2100010

• Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest

  New England Journal of Medicine · 2021 · https://doi.org/10.1056/nejmoa2100591

• Dangers of hyperoxia

  Critical Care · 2021 · https://doi.org/10.1186/s13054-021-03815-y

• The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design

  Annals of the American Thoracic Society · 2020 · https://doi.org/10.1513/annalsats.202003-192sd

• Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

  JAMA · 2020 · 10.1001/jama.2019.22190

• Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock

  JAMA · 2020 · https://doi.org/10.1001/jama.2019.22176

• Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database

  Annals of Intensive Care · 2018 · https://doi.org/10.1186/s13613-018-0448-9

• Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery

  New England Journal of Medicine · 2018 · https://doi.org/10.1056/nejmoa1808561

• Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis

  The Lancet · 2018 · https://doi.org/10.1016/s0140-6736(18)30479-3

• Angiotensin II for the Treatment of Vasodilatory Shock

  New England Journal of Medicine · 2017 · https://doi.org/10.1056/nejmoa1704154

• Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

  New England Journal of Medicine · 2017 · https://doi.org/10.1056/nejmoa1711818

• The ICU Mobility Scale Has Construct and Predictive Validity and Is Responsive. A Multicenter Observational Study

  Annals of the American Thoracic Society · 2016 · 10.1513/annalsats.201510-717oc

• A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in the ICU*

  Critical Care Medicine · 2016 · https://doi.org/10.1097/ccm.0000000000001643

• Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium

  JAMA · 2016 · https://doi.org/10.1001/jama.2016.2707

• The Fragility Index in Multicenter Randomized Controlled Critical Care Trials*

  Critical Care Medicine · 2016 · 10.1097/ccm.0000000000001670

• Acetaminophen for Fever in Critically Ill Patients with Suspected Infection

  New England Journal of Medicine · 2015 · 10.1056/nejmoa1508375

• Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit

  JAMA · 2015 · https://doi.org/10.1001/jama.2015.12334

• Conservative versus Liberal Oxygenation Targets for Mechanically Ventilated Patients. A Pilot Multicenter Randomized Controlled Trial

  American Journal of Respiratory and Critical Care Medicine · 2015 · https://doi.org/10.1164/rccm.201505-1019oc

• Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults

  Critical Care · 2014 · https://doi.org/10.1186/s13054-014-0658-y

• Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest

  Resuscitation · 2013 · 10.1016/j.resuscitation.2013.02.014

• Feasibility and inter-rater reliability of the ICU Mobility Scale

  Heart & Lung · 2013 · https://doi.org/10.1016/j.hrtlng.2013.11.003

• The effect of hyperoxia following cardiac arrest – A systematic review and meta-analysis of animal trials

  Resuscitation · 2012 · 10.1016/j.resuscitation.2011.12.021

• Early peak temperature and mortality in critically ill patients with or without infection

  Intensive Care Medicine · 2012 · 10.1007/s00134-012-2478-3

• Arterial oxygen tension and mortality in mechanically ventilated patients

  Intensive Care Medicine · 2011 · 10.1007/s00134-011-2419-6

Current projects

No projects listed.