Sean M. Grimmond

Research interests

Publications

• A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13825-8

• CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

  Nature Communications · 2019 · 10.1038/s41467-019-10968-6

• Whole-genome landscapes of major melanoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22071

• Whole–genome characterization of chemoresistant ovarian cancer

  Nature · 2015 · https://doi.org/10.1038/nature14410

• Whole genomes redefine the mutational landscape of pancreatic cancer

  Nature · 2015 · https://doi.org/10.1038/nature14169

• A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms10001

• Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

  Cell · 2014 · https://doi.org/10.1016/j.cell.2014.01.066

• Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

  Nature Communications · 2014 · 10.1038/ncomms6224

• Genome-wide characterization of the routes to pluripotency

  Nature · 2014 · https://doi.org/10.1038/nature14046

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1110156109

• The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

  Nature · 2012 · 10.1038/nature11114

• PINA v2.0: mining interactome modules

  Nucleic Acids Research · 2011 · https://doi.org/10.1093/nar/gkr967

• MicroRNAs and their isomiRs function cooperatively to target common biological pathways

  Genome biology · 2011 · https://doi.org/10.1186/gb-2011-12-12-r126

• An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.01.044

• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.375

• Tiny RNAs associated with transcription start sites in animals

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.312

• The regulated retrotransposon transcriptome of mammalian cells

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.368

• Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment

  Developmental Biology · 2009 · 10.1016/j.ydbio.2009.05.578

• Stem cell transcriptome profiling via massive-scale mRNA sequencing

  Nature Methods · 2008 · https://doi.org/10.1038/nmeth.1223

• Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

  Genome Research · 2008 · https://doi.org/10.1101/gr.078378.108

• NRED: a database of long noncoding RNA expression

  Nucleic Acids Research · 2008 · 10.1093/nar/gkn617

• The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

  Genome biology · 2008 · 10.1186/gb-2008-9-8-r127

• Genome-wide analysis of mammalian promoter architecture and evolution

  Nature Genetics · 2006 · https://doi.org/10.1038/ng1789

• Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome

  Genome Research · 2005 · https://doi.org/10.1101/gr.4200206

• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

  Nature · 2002 · https://doi.org/10.1038/nature01266

• Mice Lacking the Vascular Endothelial Growth Factor-B Gene ( Vegfb ) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia

  Circulation Research · 2000 · 10.1161/01.res.86.2.e29

Current projects

No projects listed.