Ashley I. Bush

Research interests

Publications

• A guideline on the molecular ecosystem regulating ferroptosis

  Nature Cell Biology · 2024 · https://doi.org/10.1038/s41556-024-01360-8

• Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging

  Cell Metabolism · 2022 · https://doi.org/10.1016/j.cmet.2022.01.005

• Trial of Deferiprone in Parkinson’s Disease

  New England Journal of Medicine · 2022 · https://doi.org/10.1056/nejmoa2209254

• Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis

  Cell Death and Differentiation · 2021 · https://doi.org/10.1038/s41418-021-00910-z

• Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

  Science Advances · 2020 · https://doi.org/10.1126/sciadv.abc7031

• Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

  Advanced Materials · 2018 · https://doi.org/10.1002/adma.201801362

• Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.021

• Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

  Molecular Psychiatry · 2017 · https://doi.org/10.1038/mp.2017.171

• Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms7760

• The Efficacy of AdjunctiveN-Acetylcysteine in Major Depressive Disorder

  The Journal of Clinical Psychiatry · 2014 · https://doi.org/10.4088/jcp.13m08454

• Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2613

• The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial

  Journal of Affective Disorders · 2011 · https://doi.org/10.1016/j.jad.2011.06.005

• Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.08.014

• PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

  Journal of Alzheimer s Disease · 2010 · https://doi.org/10.3233/jad-2010-1390

• Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0809057106

• The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

  International Psychogeriatrics · 2009 · https://doi.org/10.1017/s1041610209009405

• N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial

  Biological Psychiatry · 2008 · https://doi.org/10.1016/j.biopsych.2008.03.004

• Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

  The International Journal of Neuropsychopharmacology · 2008 · 10.1017/s1461145707008401

• N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

  Biological Psychiatry · 2008 · https://doi.org/10.1016/j.biopsych.2008.04.022

• Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

  The Lancet Neurology · 2008 · https://doi.org/10.1016/s1474-4422(08)70167-4

• Glutathione Precursor, N-Acetyl-Cysteine, Improves Mismatch Negativity in Schizophrenia Patients

  Neuropsychopharmacology · 2007 · https://doi.org/10.1038/sj.npp.1301624

• The neurobiology of zinc in health and disease

  Nature reviews. Neuroscience · 2005 · https://doi.org/10.1038/nrn1671

• Neurodegenerative diseases and oxidative stress

  Nature Reviews Drug Discovery · 2004 · https://doi.org/10.1038/nrd1330

• Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

  Neuron · 2001 · https://doi.org/10.1016/s0896-6273(01)00317-8

• Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion

  Journal of Biological Chemistry · 1999 · https://doi.org/10.1074/jbc.274.33.23223

• Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

  Annals of Neurology · 1999 · https://doi.org/10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m

• Rapid induction of Alzheimer A beta amyloid formation by zinc

  Science · 1994 · https://doi.org/10.1126/science.8073293

• The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

  Nature Genetics · 1993 · https://doi.org/10.1038/ng1293-344

Current projects

No projects listed.