Christopher Chen

Research interests

Publications

• The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

  The Lancet · 2023 · 10.1016/s0140-6736(23)00806-1

• Neuroimaging standards for research into small vessel disease—advances since 2013

  The Lancet Neurology · 2023 · https://doi.org/10.1016/s1474-4422(23)00131-x

• Lecanemab in Early Alzheimer’s Disease

  New England Journal of Medicine · 2022 · https://doi.org/10.1056/nejmoa2212948

• A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study

  The Lancet Digital Health · 2022 · 10.1016/s2589-7500(22)00169-8

• Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment

  Theranostics · 2022 · 10.7150/thno.68304

• Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

  The Lancet Neurology · 2021 · 10.1016/s1474-4422(21)00060-0

• The Amyloid-β Pathway in Alzheimer’s Disease

  Molecular Psychiatry · 2021 · https://doi.org/10.1038/s41380-021-01249-0

• World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

  Alzheimer s & Dementia · 2020 · https://doi.org/10.1002/alz.12123

• Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups

  Neurology · 2019 · 10.1212/wnl.0000000000008612

• Vascular dysfunction—The disregarded partner of Alzheimer's disease

  Alzheimer s & Dementia · 2019 · https://doi.org/10.1016/j.jalz.2018.07.222

• Standardized Assessment of Automatic Segmentation of White Matter Hyperintensities and Results of the WMH Segmentation Challenge

  IEEE Transactions on Medical Imaging · 2019 · 10.1109/tmi.2019.2905770

• Vascular cognitive impairment

  Nature Reviews Disease Primers · 2018 · 10.1038/nrdp.2018.3

• Spectral-Domain OCT Measurements in Alzheimer’s Disease

  Ophthalmology · 2018 · 10.1016/j.ophtha.2018.08.009

• Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study

  Alzheimer s & Dementia · 2017 · 10.1016/j.jalz.2017.09.007

• Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

  Molecular Neurobiology · 2017 · 10.1007/s12035-017-0394-9

• Detection, risk factors, and functional consequences of cerebral microinfarcts

  The Lancet Neurology · 2017 · 10.1016/s1474-4422(17)30196-5

• Imaging retina to study dementia and stroke

  Progress in Retinal and Eye Research · 2017 · 10.1016/j.preteyeres.2017.01.001

• Retinal Ganglion Cell Analysis Using High-Definition Optical Coherence Tomography in Patients with Mild Cognitive Impairment and Alzheimer's Disease

  Journal of Alzheimer s Disease · 2015 · 10.3233/jad-141659

• Diagnostic Criteria for Vascular Cognitive Disorders

  Alzheimer Disease & Associated Disorders · 2014 · https://doi.org/10.1097/wad.0000000000000034

• Microvascular network alterations in the retina of patients with Alzheimer's disease

  Alzheimer s & Dementia · 2014 · 10.1016/j.jalz.2013.06.009

• Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

  The Lancet Neurology · 2013 · https://doi.org/10.1016/s1474-4422(13)70124-8

• Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial

  The Lancet Neurology · 2010 · 10.1016/s1474-4422(10)70060-0

• The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke

  Journal of the Neurological Sciences · 2010 · 10.1016/j.jns.2010.08.051

• Hydrogen Sulfide Is a Mediator of Cerebral Ischemic Damage

  Stroke · 2006 · 10.1161/01.str.0000204184.34946.41

• Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism.

  Journal of Pharmacology and Experimental Therapeutics · 1995 · 10.1016/s0022-3565(25)10549-1

Current projects

No projects listed.