Xueling Sim

Research interests

Publications

• Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

  JAMA Oncology · 2022 · https://doi.org/10.1001/jamaoncol.2021.6744

• A saturated map of common genetic variants associated with human height

  Nature · 2022 · https://doi.org/10.1038/s41586-022-05275-y

• The trans-ancestral genomic architecture of glycemic traits

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00852-9

• Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

  Nature Genetics · 2020 · 10.1038/s41588-020-00713-x

• Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

  PLoS ONE · 2018 · https://doi.org/10.1371/journal.pone.0198166

• Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0241-6

• A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

  Diabetes · 2018 · https://doi.org/10.2337/db17-0914

• Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

  Nature Genetics · 2018 · 10.1038/s41588-018-0127-7

• Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

  PLoS Medicine · 2017 · 10.1371/journal.pmed.1002383

• Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

  Nature Genetics · 2016 · 10.1038/ng.3654

• The genetic architecture of type 2 diabetes

  Nature · 2016 · https://doi.org/10.1038/nature18642

• New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.

  Human Molecular Genetics · 2016 · https://doi.org/10.1093/hmg/ddw399

• Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

  Digital Commons@Becker (Washington University School of Medicine) · 2014 · 10.1371/journal.pgen.1004494

• Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

  Human Molecular Genetics · 2014 · 10.1093/hmg/ddu248

• Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

  The American Journal of Human Genetics · 2014 · https://doi.org/10.1016/j.ajhg.2014.01.010

• Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

  The American Journal of Human Genetics · 2013 · 10.1016/j.ajhg.2013.07.010

• Seven new loci associated with age-related macular degeneration

  Nature Genetics · 2013 · 10.1038/ng.2578

• Genome-Wide Association Study of Retinopathy in Individuals without Diabetes

  PLoS ONE · 2013 · 10.1371/journal.pone.0054232

• Meta-analysis identifies common variants associated with body mass index in east Asians

  Nature Genetics · 2012 · 10.1038/ng.1087

• Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

  Nature Genetics · 2012 · 10.1038/ng.2352

• Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

  Nature Genetics · 2012 · 10.1038/ng.2507

• Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2390

• Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

  Nature Genetics · 2011 · 10.1038/ng.1019

• Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

  Nature Genetics · 2011 · 10.1038/ng.834

• Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

  Nature Genetics · 2011 · 10.1038/ng.921

• Biological, clinical and population relevance of 95 loci for blood lipids

  Nature · 2010 · https://doi.org/10.1038/nature09270

• Identification of New Genetic Risk Variants for Type 2 Diabetes

  PLoS Genetics · 2010 · 10.1371/journal.pgen.1001127

Current projects

No projects listed.