Brian K. Kennedy

Research interests

Publications

• Biomarkers of aging for the identification and evaluation of longevity interventions

  Cell · 2023 · https://doi.org/10.1016/j.cell.2023.08.003

• Taurine deficiency as a driver of aging

  Science · 2023 · 10.1126/science.abn9257

• The quest to slow ageing through drug discovery

  Nature Reviews Drug Discovery · 2020 · 10.1038/s41573-020-0067-7

• Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

  Cell Metabolism · 2020 · 10.1016/j.cmet.2020.08.004

• The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.05.009

• Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

  Cancer Discovery · 2016 · https://doi.org/10.1158/2159-8290.cd-16-0241

• Handbook of Theories of Aging

  · 2016 · 10.1891/9780826129437

• Interventions to Slow Aging in Humans: Are We Ready?

  Aging Cell · 2015 · 10.1111/acel.12338

• A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

  Cell Metabolism · 2015 · 10.1016/j.cmet.2015.05.012

• Geroscience: Linking Aging to Chronic Disease

  Cell · 2014 · https://doi.org/10.1016/j.cell.2014.10.039

• Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

  Cell Metabolism · 2014 · https://doi.org/10.1016/j.cmet.2014.02.006

• When Lamins Go Bad: Nuclear Structure and Disease

  Cell · 2013 · 10.1016/j.cell.2013.02.015

• Replicative and Chronological Aging in Saccharomyces cerevisiae

  Cell Metabolism · 2012 · 10.1016/j.cmet.2012.06.002

• Progeria syndromes and ageing: what is the connection?

  Nature Reviews Molecular Cell Biology · 2010 · 10.1038/nrm2944

• Histone H4 lysine 16 acetylation regulates cellular lifespan

  Nature · 2009 · 10.1038/nature08085

• Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

  Cell · 2008 · 10.1016/j.cell.2008.02.037

• Sirtuins in Aging and Age-Related Disease

  Cell · 2006 · 10.1016/j.cell.2006.07.002

• Extension of chronological life span in yeast by decreased TOR pathway signaling

  Genes & Development · 2006 · https://doi.org/10.1101/gad.1381406

• Substrate-specific Activation of Sirtuins by Resveratrol

  Journal of Biological Chemistry · 2005 · 10.1074/jbc.m500655200

• Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

  Science · 2005 · https://doi.org/10.1126/science.1115535

• Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

  PLoS Biology · 2004 · 10.1371/journal.pbio.0020296

• LMNA mutations in atypical Werner's syndrome

  The Lancet · 2003 · 10.1016/s0140-6736(03)14069-x

• NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

  Genes & Development · 2000 · 10.1101/gad.827700

• Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae

  Cell · 1997 · 10.1016/s0092-8674(00)80219-6

• Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

  Cell · 1995 · 10.1016/0092-8674(95)90499-9

Current projects

No projects listed.