Yee‐Sin Leo

Research interests

Publications

• Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study

  The Lancet Microbe · 2021 · https://doi.org/10.1016/s2666-5247(21)00025-2

• Clinical and Virological Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern: A Retrospective Cohort Study Comparing B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta)

  Clinical Infectious Diseases · 2021 · 10.1093/cid/ciab721

• Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

  New England Journal of Medicine · 2021 · https://doi.org/10.1056/nejmoa2108453

• Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study

  Clinical Microbiology and Infection · 2021 · https://doi.org/10.1016/j.cmi.2021.11.010

• Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

  The Lancet · 2020 · https://doi.org/10.1016/s0140-6736(20)31757-8

• Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

  mBio · 2020 · https://doi.org/10.1128/mbio.01610-20

• Connecting clusters of COVID-19: an epidemiological and serological investigation

  The Lancet Infectious Diseases · 2020 · https://doi.org/10.1016/s1473-3099(20)30273-5

• SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts: a retrospective cohort study

  The Lancet Infectious Diseases · 2020 · https://doi.org/10.1016/s1473-3099(20)30833-1

• Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity

  Clinical Infectious Diseases · 2020 · https://doi.org/10.1093/cid/ciaa1280

• Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures

  The Lancet · 2020 · https://doi.org/10.1016/s0140-6736(20)30528-6

• A living WHO guideline on drugs for covid-19 (2020-2023)

  BMJ · 2020 · https://doi.org/10.1136/bmj.m3379

• Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-16670-2

• Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

  JAMA · 2020 · https://doi.org/10.1001/jama.2020.3204

• Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

  Nature Communications · 2020 · 10.1038/s41467-020-16638-2

• COVID-19 in Singapore—Current Experience

  JAMA · 2020 · 10.1001/jama.2020.2467

• Risk Factors for Severe Disease and Efficacy of Treatment in Patients Infected With COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis

  Clinical Infectious Diseases · 2020 · 10.1093/cid/ciaa576

• Imported Monkeypox, Singapore

  Emerging infectious diseases · 2020 · 10.3201/eid2608.191387

• Dengue Serotype-Specific Differences in Clinical Manifestation, Laboratory Parameters and Risk of Severe Disease in Adults, Singapore

  American Journal of Tropical Medicine and Hygiene · 2015 · 10.4269/ajtmh.14-0628

• Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial

  The Lancet Infectious Diseases · 2014 · 10.1016/s1473-3099(14)70730-3

• Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data

  The Lancet Respiratory Medicine · 2014 · https://doi.org/10.1016/s2213-2600(14)70041-4

• Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor

  The Journal of Infectious Diseases · 2010 · 10.1093/infdis/jiq042

• IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity

  PLoS ONE · 2009 · 10.1371/journal.pone.0004261

• Analysis of Deaths During the Severe Acute Respiratory Syndrome (SARS) Epidemic in Singapore: Challenges in Determining a SARS Diagnosis

  Archives of Pathology & Laboratory Medicine · 2004 · 10.5858/2004-128-195-aoddts

• Severe Acute Respiratory Syndrome (SARS) in Singapore: Clinical Features of Index Patient and Initial Contacts

  Emerging infectious diseases · 2003 · 10.3201/eid0906.030264

• Outbreak of Nipah-virus infection among abattoir workers in Singapore

  The Lancet · 1999 · 10.1016/s0140-6736(99)04379-2

Current projects

No projects listed.