Ruby Yun‐Ju Huang

Research interests

Publications

• Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

  Journal of Hematology & Oncology · 2025 · 10.1186/s13045-024-01634-6

• Applications of the Chick Chorioallantoic Membrane as an Alternative Model for Cancer Studies

  Cells Tissues Organs · 2021 · 10.1159/000513039

• Guidelines and definitions for research on epithelial–mesenchymal transition

  Nature Reviews Molecular Cell Biology · 2020 · https://doi.org/10.1038/s41580-020-0237-9

• Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective

  Cancers · 2020 · 10.3390/cancers12010238

• The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells

  Communications Biology · 2019 · 10.1038/s42003-019-0506-3

• The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells

  Communications Biology · 2019 · 10.1038/s42003-019-0506-3

• Stopping transformed cancer cell growth by rigidity sensing

  Nature Materials · 2019 · 10.1038/s41563-019-0507-0

• Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors

  European Urology · 2018 · 10.1016/j.eururo.2018.08.027

• Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

  Frontiers in Pharmacology · 2018 · https://doi.org/10.3389/fphar.2018.01294

• Dual role of autophagy in hallmarks of cancer

  Oncogene · 2017 · https://doi.org/10.1038/s41388-017-0046-6

• AXL-Driven EMT State as a Targetable Conduit in Cancer

  Cancer Research · 2017 · https://doi.org/10.1158/0008-5472.can-17-0392

• A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets

  Cancer Letters · 2016 · 10.1016/j.canlet.2016.09.001

• Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

  OncoImmunology · 2016 · 10.1080/2162402x.2016.1191731

• EMT: 2016

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.06.028

• GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification

  Scientific Reports · 2016 · 10.1038/srep19943

• The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype–specific therapeutic target for ovarian cancer

  Science Signaling · 2016 · 10.1126/scisignal.aaf8175

• Lgr5 marks stem/progenitor cells in ovary and tubal epithelia

  Nature Cell Biology · 2014 · https://doi.org/10.1038/ncb3000

• FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway

  Cell Death and Disease · 2014 · 10.1038/cddis.2014.302

• Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

  EMBO Molecular Medicine · 2014 · https://doi.org/10.15252/emmm.201404208

• An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

  Cell Death and Disease · 2013 · 10.1038/cddis.2013.442

• Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer

  EMBO Molecular Medicine · 2013 · 10.1002/emmm.201201823

• Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

  Integrative Biology · 2012 · 10.1039/c2ib20209c

• Early events in cell adhesion and polarity during epithelial-mesenchymal transition

  Journal of Cell Science · 2012 · 10.1242/jcs.099697

• Epithelial-Mesenchymal Transitions in Development and Disease

  Cell · 2009 · https://doi.org/10.1016/j.cell.2009.11.007

• Pure-type clear cell carcinoma of the ovary as a distinct histological type and improved survival in patients treated with paclitaxel-platinum-based chemotherapy in pure-type advanced disease

  Gynecologic Oncology · 2004 · 10.1016/j.ygyno.2004.04.004

Current projects

No projects listed.