John Blangero

Research interests

Publications

• Clonal haematopoiesis and risk of chronic liver disease

  Nature · 2023 · https://doi.org/10.1038/s41586-023-05857-4

• Genetic diversity fuels gene discovery for tobacco and alcohol use

  Nature · 2022 · 10.1038/s41586-022-05477-4

• Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01165-1

• Brain charts for the human lifespan

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04554-y

• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03205-y

• A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00935-7

• Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0676-4

• Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0676-4

• Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

  Nature · 2019 · 10.1038/s41586-019-1231-2

• Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

  PLoS Genetics · 2019 · https://doi.org/10.1371/journal.pgen.1008500

• Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms14977

• Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

  PLoS Genetics · 2017 · 10.1371/journal.pgen.1006528

• Long-term neural and physiological phenotyping of a single human

  Nature Communications · 2015 · 10.1038/ncomms9885

• Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2915

• The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

  Brain Imaging and Behavior · 2014 · https://doi.org/10.1007/s11682-013-9269-5

• Plasma lipid profiling in a large population-based cohort

  Journal of Lipid Research · 2013 · 10.1194/jlr.p035808

• Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group

  NeuroImage · 2013 · 10.1016/j.neuroimage.2013.04.061

• A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2274

• Fractional anisotropy of water diffusion in cerebral white matter across the lifespan

  Neurobiology of Aging · 2010 · 10.1016/j.neurobiolaging.2010.01.014

• Genetic control over the resting brain

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.0909969107

• Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies

  NeuroImage · 2009 · 10.1016/j.neuroimage.2009.12.028

• Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes

  Nature Genetics · 2007 · 10.1038/ng2119

• Genetic variation in selenoprotein S influences inflammatory response

  Nature Genetics · 2005 · 10.1038/ng1655

• Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees

  Science · 2000 · 10.1126/science.290.5500.2303

• Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.97.26.14478

• Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans

  The American Journal of Human Genetics · 1999 · 10.1086/302316

• An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body-Mass Index in Pima Indians

  The American Journal of Human Genetics · 1998 · 10.1086/302061

• Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees

  The American Journal of Human Genetics · 1998 · 10.1086/301844

• Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages

  Genetic Epidemiology · 1997 · 10.1002/(sici)1098-2272(1997)14:6<953::aid-gepi65>3.0.co;2-k

• A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

  Nature Genetics · 1997 · 10.1038/ng0397-273

• Genetic and Environmental Contributions to Cardiovascular Risk Factors in Mexican Americans

  Circulation · 1996 · 10.1161/01.cir.94.9.2159

Current projects

No projects listed.