Patrick Sung

Research interests

Publications

• The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication

  Nature Reviews Molecular Cell Biology · 2020 · https://doi.org/10.1038/s41580-020-0218-z

• BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

  Nature · 2017 · https://doi.org/10.1038/nature24060

• 53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks

  Molecular and Cellular Biology · 2014 · https://doi.org/10.1128/mcb.01639-13

• Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

  Nature · 2013 · https://doi.org/10.1038/nature12585

• Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

  Nature · 2010 · https://doi.org/10.1038/nature09318

• Mechanism of Eukaryotic Homologous Recombination

  Annual Review of Biochemistry · 2008 · https://doi.org/10.1146/annurev.biochem.77.061306.125255

• RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

  Genes & Development · 2007 · https://doi.org/10.1101/gad.1609107

• Mechanism of homologous recombination: mediators and helicases take on regulatory functions

  Nature Reviews Molecular Cell Biology · 2006 · https://doi.org/10.1038/nrm2008

• Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome

  DNA repair · 2005 · https://doi.org/10.1016/j.dnarep.2005.09.005

• Crosstalk between SUMO and Ubiquitin on PCNA Is Mediated by Recruitment of the Helicase Srs2p

  Molecular Cell · 2005 · https://doi.org/10.1016/j.molcel.2005.06.001

• Rad51 Recombinase and Recombination Mediators

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.r300027200

• DNA helicase Srs2 disrupts the Rad51 presynaptic filament

  Nature · 2003 · https://doi.org/10.1038/nature01577

• Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

  Journal of Biological Chemistry · 1998 · https://doi.org/10.1074/jbc.273.34.21447

• Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins

  Nature · 1998 · https://doi.org/10.1038/30037

• DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

  Cell · 1995 · https://doi.org/10.1016/0092-8674(95)90434-4

• Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.

  Genes & Development · 1994 · https://doi.org/10.1101/gad.8.7.811

• Human xeroderma pigmentosum group D gene encodes a DMA helicase

  Nature · 1993 · https://doi.org/10.1038/365852a0

Current projects

No projects listed.