Guangping Gao

Research interests

Publications

• Adeno-associated virus as a delivery vector for gene therapy of human diseases

  Signal Transduction and Targeted Therapy · 2024 · 10.1038/s41392-024-01780-w

• Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

  Nature Biotechnology · 2023 · 10.1038/s41587-023-01679-x

• Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

  Nature Biotechnology · 2022 · 10.1038/s41587-022-01527-4

• Viral vector platforms within the gene therapy landscape

  Signal Transduction and Targeted Therapy · 2021 · https://doi.org/10.1038/s41392-021-00487-6

• CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

  Cell · 2020 · 10.1016/j.cell.2020.03.023

• Adeno-associated virus vector as a platform for gene therapy delivery

  Nature Reviews Drug Discovery · 2019 · https://doi.org/10.1038/s41573-019-0012-9

• Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

  Immunity · 2019 · 10.1016/j.immuni.2019.12.004

• Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

  Nature Communications · 2017 · 10.1038/s41467-017-00406-w

• Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

  Nature Biotechnology · 2016 · https://doi.org/10.1038/nbt.3471

• AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

  Nature · 2015 · 10.1038/nature14264

• Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

  Human Gene Therapy · 2015 · 10.1089/hum.2015.087

• Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

  The Journal of Infectious Diseases · 2009 · 10.1086/595830

• New Recombinant Serotypes of AAV Vectors

  Current Gene Therapy · 2005 · 10.2174/1566523054065057

• Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

  Journal of Virology · 2004 · https://doi.org/10.1128/jvi.78.12.6381-6388.2004

• Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

  Molecular Genetics and Metabolism · 2003 · https://doi.org/10.1016/j.ymgme.2003.08.016

• Adeno-associated viruses undergo substantial evolution in primates during natural infections

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.0937739100

• Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

  Proceedings of the National Academy of Sciences · 2002 · 10.1073/pnas.182412299

• A Pilot Study of In Vivo Liver-Directed Gene Transfer with an Adenoviral Vector in Partial Ornithine Transcarbamylase Deficiency

  Human Gene Therapy · 2002 · 10.1089/10430340152712719

• Acute Cytokine Response to Systemic Adenoviral Vectors in Mice Is Mediated by Dendritic Cells and Macrophages

  Molecular Therapy · 2001 · 10.1006/mthe.2001.0329

• Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver

  Molecular Therapy · 2001 · 10.1006/mthe.2000.0227

• Activation of Innate Immunity in Nonhuman Primates Following Intraportal Administration of Adenoviral Vectors

  Molecular Therapy · 2001 · 10.1006/mthe.2001.0330

• Isolation of Highly Infectious and Pure Adeno-Associated Virus Type 2 Vectors with a Single-Step Gravity-Flow Column

  Human Gene Therapy · 2001 · 10.1089/104303401450988

• Gene Therapy Vectors Based on Adeno-Associated Virus Type 1

  Journal of Virology · 1999 · 10.1128/jvi.73.5.3994-4003.1999

• Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer

  Science · 1999 · 10.1126/science.283.5398.88

• Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy

  Journal of Virology · 1996 · 10.1128/jvi.70.12.8934-8943.1996

Current projects

No projects listed.