Asrar B. Malik

Research interests

Publications

• Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

  eLife · 2020 · 10.7554/elife.51413

• mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

  Immunity · 2020 · 10.1016/j.immuni.2020.02.002

• The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

  Immunity · 2018 · 10.1016/j.immuni.2018.04.032

• Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

  Journal of Clinical Investigation · 2017 · 10.1172/jci94495

• Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability

  Circulation Research · 2017 · 10.1161/circresaha.116.306534

• Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.10.006

• Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils

  Nature Nanotechnology · 2014 · 10.1038/nnano.2014.17

• Reactive Oxygen Species in Inflammation and Tissue Injury

  Antioxidants and Redox Signaling · 2013 · https://doi.org/10.1089/ars.2012.5149

• Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

  Annual Review of Physiology · 2010 · 10.1146/annurev-physiol-021909-135833

• Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway

  The Journal of Immunology · 2009 · 10.4049/jimmunol.0802884

• Size and Dynamics of Caveolae Studied Using Nanoparticles in Living Endothelial Cells

  ACS Nano · 2009 · 10.1021/nn9012274

• Regulation of Endothelial Junctional Permeability

  Annals of the New York Academy of Sciences · 2008 · 10.1196/annals.1420.016

• NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

  Antioxidants and Redox Signaling · 2008 · 10.1089/ars.2008.2220

• NF-κB activation as a pathological mechanism of septic shock and inflammation

  American Journal of Physiology-Lung Cellular and Molecular Physiology · 2006 · 10.1152/ajplung.00477.2005

• Signaling Mechanisms Regulating Endothelial Permeability

  Physiological Reviews · 2005 · https://doi.org/10.1152/physrev.00012.2005

• Caveolin regulation of endothelial function

  American Journal of Physiology-Lung Cellular and Molecular Physiology · 2003 · 10.1152/ajplung.00242.2003

• Impairment of Store-Operated Ca 2+ Entry in TRPC4 −/− Mice Interferes With Increase in Lung Microvascular Permeability

  Circulation Research · 2002 · 10.1161/01.res.0000023391.40106.a8

• Role of Ca2+ signaling in the regulation of endothelial permeability

  Vascular Pharmacology · 2002 · 10.1016/s1537-1891(03)00007-7

• Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway

  The Journal of Cell Biology · 2000 · 10.1083/jcb.150.5.1057

• Inhibition of NF-κB Activation by Pyrrolidine Dithiocarbamate Prevents In Vivo Expression of Proinflammatory Genes

  Circulation · 1999 · 10.1161/01.cir.100.12.1330

• Gp60 Activation Mediates Albumin Transcytosis in Endothelial Cells by Tyrosine Kinase-dependent Pathway

  Journal of Biological Chemistry · 1997 · 10.1074/jbc.272.41.25968

• Regulation of vascular endothelial barrier function

  American Journal of Physiology-Lung Cellular and Molecular Physiology · 1994 · 10.1152/ajplung.1994.267.3.l223

• Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion.

  The Journal of Cell Biology · 1992 · 10.1083/jcb.119.4.935

• Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.17.7919

• Thrombin‐induced increase in albumin permeability across the endothelium

  Journal of Cellular Physiology · 1986 · 10.1002/jcp.1041280115

Current projects

No projects listed.